DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11407 and acs-1

DIOPT Version :9

Sequence 1:	NP_650831.1	Gene:	CG11407 / 42354	FlyBaseID:	FBgn0038733	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001023937.1	Gene:	acs-1 / 179043	WormBaseID:	WBGene00018488	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	123/527 - (23%)
Similarity:	216/527 - (40%)	Gaps:	96/527 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SIGEIIFNEMRRHPQLIAQISATENTILTRAELQANAMHIASYMRSLGLLQMDIVGIIARNTTHI 94
            ::|:.:.:.:.:.|.....|...|....|.:::..:|.::|..:..|||.:.|.:||...||...
Worm    67 TVGDRLRSAVDQVPDKEFLIFKREGIRKTYSQVATDAENLACGLLHLGLKKGDRIGIWGPNTYEW 131

  Fly    95 SAVAYACFFNGIAFHSLNISYEQS----TIEKL---FSITRPNIIFCDGDEFEKVRSATAQLDVK 152
            :...:|....|:...::|.||:..    .|||:   ..||.|.  |...:.::.::....::.:|
Worm   132 TTTQFASALAGMVLVNINPSYQSEELRYAIEKVGIRALITPPG--FKKSNYYQSIKDILPEVTLK 194

  Fly   153 I-----ITMRN----------------HPSGSIRIDQVLS----------TPIEKNFQPVRLEQG 186
            .     ||.||                :| |:.:...|:.          :.||:..||
Worm   195 EPGKSGITSRNFTCFQHLIMFDEEDKIYP-GAWKYTDVMKMGTEEDRHHLSKIERETQP------ 252

  Fly   187 NDQTLAILCSSGTTGIPKAVTITNSRQILNSSHSL--------------TTNDVQYSHSTLDWIT 237
             |.:|.|..:|||||.||..|:|: ..:||::..:              ..|.:.:....:..:.
Worm   253 -DDSLNIQYTSGTTGQPKGATLTH-HNVLNNAFFVGLRAGYSEKKTIICIPNPLYHCFGCVMGVL 315

  Fly   238 GLLTTVTSGVFSTKRIIADNIFDPEFFMRLVEEHQITWIIQAPAHMAMMVNSPSFTTSDLSSLRY 302
            ..||.:.:.||....      ||....::.:.|.:.|.:...|.....|:|.|.:...:..|:|.
Worm   316 AALTHLQTCVFPAPS------FDALAALQAIHEEKCTALYGTPTMFIDMINHPEYANYNYDSIRS 374

  Fly   303 YLFGGSRASVETQHRIRSRLSKDCLHFAYGFTELGSMAALNLHFD---EKPNSVGRLVAGLKLKV 364
            ....|:...:....|:...:....:...||.||...::.::...|   ::..|||.::..|:..:
Worm   375 GFIAGAPCPITLCRRLVQDMHMTDMQVCYGTTETSPVSFMSTRDDPPEQRIKSVGHIMDHLEAAI 439

  Fly   365 ICEKGESLGPDEV-GEL---------CLWNGQYWAGYYGNPEETHKMRDHHNWFHTGDLGYVDDD 419
            : :|...:.|..| ||:         |.||.:         |:|.|......|:||||:..:.|:
Worm   440 V-DKRNCIVPRGVKGEVIVRGYSVMRCYWNSE---------EQTKKEITQDRWYHTGDIAVMHDN 494

  Fly   420 GFIYIVERKKDMLKFQNIMYYPNEIESVISKMPDVVEVCVFGVWNEINGDEATAAVVKKRGSA-- 482
            |.|.||.|.|||:.......||.|:|..:.|...|.:|.:.||.:|..| |...|.|:...||
Worm   495 GTISIVGRSKDMIVRGGENIYPTEVEQFLFKHQSVEDVHIVGVPDERFG-EVVCAWVRLHESAEG 558

  Fly   483 -LTAQDI 488
             .|.:||
Worm   559 KTTEEDI 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11407	NP_650831.1	CaiC	26..523	CDD:223395	123/527 (23%)
CG11407	NP_650831.1	Firefly_Luc_like	47..522	CDD:213279	121/510 (24%)
acs-1	NP_001023937.1	PRK08315	53..615	CDD:236236	123/527 (23%)
acs-1	NP_001023937.1	FACL_like_2	252..604	CDD:213284	85/339 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860