DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11407 and acs-6

DIOPT Version :9

Sequence 1:	NP_650831.1	Gene:	CG11407 / 42354	FlyBaseID:	FBgn0038733	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_495450.1	Gene:	acs-6 / 174156	WormBaseID:	WBGene00022849	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	132/556 - (23%)
Similarity:	228/556 - (41%)	Gaps:	69/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SIGEIIFNEMRRHPQ-------LIAQISATENTILTRAELQANAMHIASYMRSLGLLQMDIVGII 87
            ::.|.||...|.|..       .|...:.|:..:....|...|:  :|:.:..||....|:....
Worm    16 TVHERIFEACRIHASANKDAVCFIDAETTTKKKLYKDVEPTVNS--LATALVKLGFKPGDVASQA 78

  Fly    88 ARNTTHISAVAYACFFNGIAFHSLNISYEQSTIEKLFSITRPNIIFCDGDEFEKVRSATAQLD-- 150
            ..|.........|....|.|..:.:..:....::..|..:..:|:|.|.|...::|.|||:..
Worm    79 FPNCPEFLVAMLAVMKCGGAMSNASAIFTDYELQLQFCDSNTSIVFTDEDRLARIRRATAKCPGV 143

  Fly   151 VKIITMRNHPSGSIRIDQVL------STPIEKNFQPVRLEQGNDQTLAILCSSGTTGIPKAVTIT 209
            .|||.:|..|..:...:.||      .||    .||:.:....|....:..||||||.||...:|
Worm   144 RKIICLRTFPLRTEFPENVLDYVELTQTP----DQPINVNVSMDSIALLPYSSGTTGRPKGCQLT 204

  Fly   210 --NSRQILNSSHSLTTNDV--------------QYSHSTLDW-----ITGLLTTVTSGVFSTKRI 253
              |...:|:.:.:....||              :::...|.|     :..:..|:..|:..
Worm   205 HRNIGAMLDVAKAHLETDVAPAMFGKEKATWHKEHTVLLLPWYHAYGLNTMFETILLGMTG---- 265

  Fly   254 IADNIFDPEFFMRLVEEHQI--TWIIQAPAHMAMMVNSPS---FTTSDLSSLRYYLFGGSRASVE 313
            |....||....:..::.:::  .|::  |..:..:...|.   |.|:..  |:..:..|:.|..:
Worm   266 IVFKKFDTIVMLNRIKFYKVKLAWLV--PPMLIFLAKDPMVPIFNTAPF--LKVIMSAGATAGKQ 326

  Fly   314 TQHRIRSRLSKDCLHFAYGFTELGSMAALNLHFDEKP--NSVGRLVAGLKLKVI-CEKGESLGPD 375
            ....:..|.....|..|||.||:.....:. .|::..  .:||.|.:..:||:: .||.|....:
Worm   327 LCEEVSKRFPNAWLCQAYGMTEMVQFTTIP-RFEDGNCFETVGNLASTYELKILDKEKKEITTIN 390

  Fly   376 EVGELCLWNGQYWAGYYGNPEETHKMRDHHNWFHTGDLGYVDDDGFIYIVERKKDMLKFQNIMYY 440
            .||:||........||.  ..|...:.|...:..|||||.:||.|.|::..|.|:::|...:...
Worm   391 TVGQLCFRGPTVMKGYL--KREEADIIDKDGFLLTGDLGSIDDKGRIHVTGRIKELIKVNGMQVP 453

  Fly   441 PNEIESVISKMPDVVEVCVFGVWNEINGDEATAAVVKKRGSALTAQDIVDYVETHIDAKYKQLNG 505
            |.|||.|:...|.|.:..|.||.:|..|:...|.:||| ...||..::.::|...: :.||.::.
Worm   454 PVEIEDVLLLHPKVKDCAVIGVPDEHKGESPKAYIVKK-DHTLTEAELTEFVRQKL-SSYKWIDT 516

  Fly   506 GAIIVEDLVRSPNGKTNR-----MANKAFFLEAKSS 536
            ...| :.:.:.|:||..|     ||..:...|:::|
Worm   517 YEFI-DSIPKLPSGKIQRKKLKKMAESSGSTESEAS 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11407	NP_650831.1	CaiC	26..523	CDD:223395	127/536 (24%)
CG11407	NP_650831.1	Firefly_Luc_like	47..522	CDD:213279	121/511 (24%)
acs-6	NP_495450.1	CaiC	15..541	CDD:223395	129/544 (24%)
acs-6	NP_495450.1	Firefly_Luc_like	37..532	CDD:213279	122/514 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840