DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11407 and ACSM1

DIOPT Version :9

Sequence 1:	NP_650831.1	Gene:	CG11407 / 42354	FlyBaseID:	FBgn0038733	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001305819.1	Gene:	ACSM1 / 116285	HGNCID:	18049	Length:	577	Species:	Homo sapiens

Alignment Length:	509	Identity:	114/509 - (22%)
Similarity:	194/509 - (38%)	Gaps:	101/509 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 YMRSLGLLQMDIVGIIARNTTHISAVAYACFFNGIAFHSLNISYEQSTIEKLFSITR-PNIIFCD 135
            :.::.||.|.|.:.::.........||..|...||.|....|..:...|.....::: ..|:..|
Human   102 FTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTID 166

  Fly   136 --GDEFEKVRSATAQLDVKIITMRNHPSGSIRIDQVLSTPI-------EKNFQPVRLEQGNDQTL 191
              ..|.:.:.|....|..|::...:...|.:....::.:..       .|...|          :
Human   167 ALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDP----------M 221

  Fly   192 AILCSSGTTGIPKAV----------TITNSRQILNSSHSLTTNDVQYSHSTLDWITGLLTTV--- 243
            .|..:|||||.||..          :...||::    .||.|:||.:..|...||...:.|:
Human   222 VIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKL----RSLKTSDVSWCLSDSGWIVATIWTLVEP 282

  Fly   244 -TSGV---------FSTKRIIADNIFDPEFFMRLVEEHQITWIIQAPAHMAMMVNSPSFTTSDLS 298
             |:|.         |.||.||       :..::....|  .|.:.:   :..|:....||:....
Human   283 WTAGCTVFIHHLPQFDTKVII-------QTLLKYPINH--FWGVSS---IYRMILQQDFTSIRFP 335

  Fly   299 SLRYYLFGGSRASVETQHRIRSRLSKDCLHFAYGFTELGSMAALNLHFDEKPNSVGRLVAGLKLK 363
            :|.:...||.....:.|...:.|... .|:..||.:|.|.:.|.......||..:|:......::
Human   336 ALEHCYTGGEVVLPKDQEEWKRRTGL-LLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQ 399

  Fly   364 VICEKGESLGPDEVGE--------------LCLWNGQYWAGYYGNPEETHKMRDHHNWFHTGDLG 414
            ||.:||..|.|:..|.              :|         |.|:||:|.|: :..::::|||.|
Human   400 VIDDKGSILPPNTEGNIGIRIKPVRPVSLFMC---------YEGDPEKTAKV-ECGDFYNTGDRG 454

  Fly   415 YVDDDGFIYIVERKKDMLKFQNIMYYPNEIESVISKMPDVVEVCVFGVWNEINGDEATAAVVKKR 479
            .:|::|:|..:.|..|::........|.|:||.:.:.|.|.|..|.|..:.|.|:...|.:|
Human   455 KMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIV--- 516

  Fly   480 GSALTAQ-------DIVDYVETH---IDAKYKQLNGGAIIVEDLVRSPNGKTNR 523
               ||.|       .:...::.|   :.|.||... ....|.:|.::..||..|
Human   517 ---LTPQFLSHDKDQLTKELQQHVKSVTAPYKYPR-KVEFVSELPKTITGKIER 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11407	NP_650831.1	CaiC	26..523	CDD:223395	113/507 (22%)
CG11407	NP_650831.1	Firefly_Luc_like	47..522	CDD:213279	113/506 (22%)
ACSM1	NP_001305819.1	MACS_euk	45..574	CDD:341251	114/509 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920