DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11391 and DIP2B

DIOPT Version :9

Sequence 1:	NP_650830.1	Gene:	CG11391 / 42353	FlyBaseID:	FBgn0038732	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	651	Identity:	131/651 - (20%)
Similarity:	222/651 - (34%)	Gaps:	204/651 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HSLYNEELTVGQIIFRQLQRQPQRI-FQISHTDNTRLTRFQMLQ---NAAKIGCYLRDQGFKKET 85
            :.|..:...:.:|:..:.|..|..: |.:.:...|.:.....||   .|.:|...|.|:|.....
Human   982 NDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDKGHLNAG 1046

  Fly    86 DLVGLMARNSTHVGALAYGCLFNG------TPFHAVNPNLEHNTISSLYKITRPRILCCDTADYE 144
            |.|.|:......:.|..||||:.|      .|.||.|......|:..:..:::   ..|......
Human  1047 DNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSK---AACILTSQT 1108

  Fly   145 KIKDIGASLGALIITVNGKLPGVISVADILQNPLPDDYEPAQFQRGVDRTMAIL-CSSGTTGTPK 208
            .::.:.:...|..:.|. ..|.:|...|:.:..||..|:|.     ....:|.| .|..|||...
Human  1109 LMRLLRSREAAAAVDVK-TWPTIIDTDDLPRKRLPQLYKPP-----TPEMLAYLDFSVSTTGMLT 1167

  Fly   209 AVTLSNSR--------KL-FEMHS------------------------YLGSDDVQYAPSTLD-- 238
            .|.:|:|.        || .|::|                        |.|...|...|..|:
Human  1168 GVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLIPPMELENN 1232

  Fly   239 ---WLT--------------GLITLVTAAVFGTVRLISS------------------------EM 262
               ||:              .::.|.|..:...|.::.:                        :.
Human  1233 LFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCVRTCVVVAEERPRVALQQS 1297

  Fly   263 FSTAHFLDI-CEQHEVSWTIMANSHVAMLANC--------PKTSAQKLRSLKHLLFAGGHCLVAT 318
            ||.. |.|| .....||.|..:..:||:   |        |.|....|:||:|
Human  1298 FSKL-FKDIGLSPRAVSTTFGSRVNVAI---CLQGTSGPDPTTVYVDLKSLRH------------ 1346

  Fly   319 LKKMQSFLHGSGILRNAYGLTEVGTLVSYNYDTQSKPTSV-----GRLMANIRVKIVDSSGQLQG 378
                           :...|.|.|.           |.|:     |:::..::|.||:.  :.:|
Human  1347 ---------------DRVRLVERGA-----------PQSLLLSESGKILPGVKVVIVNP--ETKG 1383

  Fly   379 PKG---LGEILCHNGQPWSGY-------------------VGNPLATAEMRDSAGWYHTGDVGYF 421
            |.|   ||||..::....|||                   .|:...|.       |..||.:|:.
Human  1384 PVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTL-------WARTGYLGFV 1441

  Fly   422 ---------DEDH-YLHIVERKKDMLKYLGMMYYPHEVEEVIAQM-PDVAEVCVFGIFRETEGDA 475
                     .|.| .|::|....:.|:..|:.|:|.::|..:::: ..:||..||     |..:.
Human  1442 RRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVF-----TWTNL 1501

  Fly   476 AAASVVLRSGSKLDPKHVEQYVRKNVSVQFKHLHGGVQFVPQ---LAKSANGKVNRQAVKAAYLR 537
            ....|.| .||:.:...:...| .||.::..:|..||..|..   :..::.|:..|..::.::|.
Human  1502 LVVVVEL-CGSEQEALDLVPLV-TNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLA 1564

  Fly   538 D 538
            |
Human  1565 D 1565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11391	NP_650830.1	CaiC	24..541	CDD:223395	131/651 (20%)
CG11391	NP_650830.1	AFD_class_I	51..527	CDD:302604	123/611 (20%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395
		AFD_class_I	360..924	CDD:302604
		AMP-binding	995..1470	CDD:278902	105/534 (20%)
		AFD_class_I	1012..1565	CDD:302604	125/619 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900