DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11391 and CG4563

DIOPT Version :9

Sequence 1:	NP_650830.1	Gene:	CG11391 / 42353	FlyBaseID:	FBgn0038732	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	202/528 - (38%)
Similarity:	303/528 - (57%)	Gaps:	9/528 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TSYDPVQKVWSGCSRHSLYNEELTVGQIIFRQLQRQPQRIFQISHTDNTRLTRFQMLQNAAKIGC 74
            |.::...:||||..|.::|:...:||||:|..|:..|..:.||:..|.|.||...||..|.:|..
  Fly     9 TFFNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIAL 73

  Fly    75 YLRDQGFKKETDLVGLMARNSTHVGALAYGCLFNGTPFHAVNPNLEHNTISSLYKITRPRILCCD 139
            :.:.:|..:| |.||::|.:||.|..:|..|.|..|||||||.:.|...:..||.:|:|:|:..|
  Fly    74 FFKSEGLTQE-DRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFID 137

  Fly   140 TADYEKIKDIGASLGALIITVNGKLPGVISVADILQ-NPLPDDYEPAQFQRGVDRTMAILCSSGT 203
            ..||::||:|.......:||:.||:.||.|:.|::: :|....|.||....|.|:...:||||||
  Fly   138 GPDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGT 202

  Fly   204 TGTPKAVTLSNSRKLFEMHSYLGSDDVQYAPSTLDWLTGLITLVTAAVFGTVRLISSEMFSTAHF 268
            .|.||||.||: |.:...:|...|.||.|..:|:||:||....|.....|..|:||...||....
  Fly   203 AGLPKAVALSH-RHIASTNSLCISTDVLYTSATIDWMTGFSITVMNLTCGFTRIISRRTFSAETA 266

  Fly   269 LDICEQHEVSWTIMANSHVAMLANCPKTSAQKLRSLKHLLFAGGHCLVATLKKMQSFLHGSGILR 333
            |.:..:::|:...||......|...|..::::|.|||.....||...:|.|::.|..|..:.::
  Fly   267 LYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQELLPKTYVM- 330

  Fly   334 NAYGLTEVGTLVSYNYDTQSKPTSVGRLMANIRVKIVDSSGQLQGPKGLGEILCHNGQPWSGYVG 398
            .:||.||.| :|:.|.| .|...|||||...:|:||....||..|....||:|...|..|.||:.
  Fly   331 FSYGTTETG-VVTINID-HSLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDIGLKWEGYLS 393

  Fly   399 NPLATA-EMRDSAGWYHTGDVGYFDEDHYLHIVERKKDMLKYLGMMYYPHEVEEVIAQMPDVAEV 462
            ||..|| .::|  ||.:.||:||||||:.|::|:||||:|||....|:|:|:|::||::|:|..|
  Fly   394 NPEDTATTLQD--GWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVEHV 456

  Fly   463 CVFGIFRETEGDAAAASVVLRSGSKLDPKHVEQYVRKNVSVQFKHLHGGVQFVPQLAKSANGKVN 527
            ||.|:.....||||.|.::.:.|:::..:.|..:|.:.|.|.:|.|:.||.||.:..|:|||||.
  Fly   457 CVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKNANGKVM 521

  Fly   528 RQAVKAAY 535
            |...:..:
  Fly   522 RSLAREVF 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11391	NP_650830.1	CaiC	24..541	CDD:223395	197/514 (38%)
CG11391	NP_650830.1	AFD_class_I	51..527	CDD:302604	186/477 (39%)
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	197/516 (38%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	186/478 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471310
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	10	9.860