Protein Alignment Acsx2 and ACSL3

DIOPT Version :10

• Sequence 1: NP_650830.1
• Gene: Acsx2 / 42353
• FlyBaseID: FBgn0038732
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_004448.2
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 140/602 - (23%)
• Similarity: 219/602 - (36%)
• Gaps: 188/602 - (31%)

  Fly     4 LNGNPATSYDPVQK-------VWSGC---------SRHSLYNEELT-VGQIIFRQLQRQPQ-RIF 50
            :|..|.::|..|..       ::.||         :::...|:.|. ..:::..:.:.||. :||
Human    60 VNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIF 124

  Fly    51 Q---------ISHTDNTRLTRFQMLQNAAKIGCYLRDQGFKKETDLVGLMARNSTHVGALAYGC- 105
            :         :|:.|        :...|...|..|:..|.|.:|: :.:...........|..|
Human   125 KKVILGQYNWLSYED--------VFVRAFNFGNGLQMLGQKPKTN-IAIFCETRAEWMIAAQACF 180

  Fly   106 LFN----------GTP--FHAVNPNLEHNTISSLYKITRPRILCCDTADYEKIKDIGASLGAL-- 156
            ::|          |.|  .||:|.....|.|:|...:            ..|:|||.:.:..|
Human   181 MYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELL------------QTKLKDIVSLVPRLRH 233

  Fly   157 IITVNGKLP-------GVI--SVADI--------LQN-----PLPDDYEPAQFQRGVDRTMAILC 199
            ||||:||.|       |:|  ::|.:        ::|     |||.|            ...|:.
Human   234 IITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSD------------IAVIMY 286

  Fly   200 SSGTTGTPKAVTLSNSR------KLFEMHSYLGSDDVQY-------------------------- 232
            :||:||.||.|.:|:|.      .:.|....||.:||..
Human   287 TSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGY 351

  Fly   233 -APSTLDWLTGLI-------------TLVTAA------VFGTVRLISSEMFSTAHFLDICEQHEV 277
             :|.||...:..|             ||:.|.      ::..|....|||.|....|.|...:..
Human   352 SSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYK 416

  Fly   278 SWTIMANSHVAMLANCPKTSAQKLRSLK----HLLFAGGHCLVATLKKMQSFLH----GSGILRN 334
            ...|....:..:   |.....:|:|||.    .||..||..|.||.::..:...    |.|
Human   417 MEQISKGRNTPL---CDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQG---- 474

  Fly   335 AYGLTE---VGTLVS-YNYDTQSKPTSVGRLMA-----NIRVKIVDSSG--QLQGPKGLGEILCH 388
             |||||   .||:.. ::|:|       ||:.|     .|::|..:..|  ....|...||||..
Human   475 -YGLTESAGAGTISEVWDYNT-------GRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIG 531

  Fly   389 NGQPWSGYVGNPLATA----EMRDSAGWYHTGDVGYFDEDHYLHIVERKKDMLKYLGMMYYP-HE 448
            ......||..|...|.    |..:...|..|||:|.|:.|..|.|::||||::|.....|.. .:
Human   532 GQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGK 596

  Fly   449 VEEVIAQMPDVAEVCVF 465
            ||..:..:|.|..:|.:
Human   597 VEAALKNLPLVDNICAY 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acsx2	NP_650830.1	Firefly_Luc_like	51..527	CDD:341237	128/537 (24%)
ACSL3	NP_004448.2	Adenylate forming domain, Class I superfamily	30..717	CDD:473059	140/602 (23%)