DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11391 and ACSL1

DIOPT Version :9

Sequence 1:	NP_650830.1	Gene:	CG11391 / 42353	FlyBaseID:	FBgn0038732	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001273637.1	Gene:	ACSL1 / 2180	HGNCID:	3569	Length:	698	Species:	Homo sapiens

Alignment Length:	555	Identity:	119/555 - (21%)
Similarity:	199/555 - (35%)	Gaps:	150/555 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YDPVQKVWSGCSRH-SLYNEELTVGQIIFRQLQRQPQRIFQISHTDNTRLTRFQMLQNAAKIGCY 75
            ||.|..::.|..|. .:.|....:|       .|:|.:.::       .|:..|:.:.:..||..
Human    86 YDDVTTLYEGFQRGIQVSNNGPCLG-------SRKPDQPYE-------WLSYKQVAELSECIGSA 136

  Fly    76 LRDQGFKKETD-LVGLMARNSTHVGALAYGCLFNGTPFHAVNPNLEHNTISSLYKITRPRILCCD 139
            |..:|||...| .:|:.|:|......:..||.........:...|.:..|:.:.......::..|
Human   137 LIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVD 201

  Fly   140 TADYEKIKDIGASLGALIITVNGKL-PG--VISVADILQNPLPDDYEPAQFQR-GVDRT------ 194
            ..:..|:         |:..|..|| ||  :|.|.|...:.|.:     :.|| ||:.|
Human   202 KPEKAKL---------LLEGVENKLIPGLKIIVVMDAYGSELVE-----RGQRCGVEVTSMKAME 252

  Fly   195 -----------------MAILC-SSGTTGTPKAVTLSNSRKLFEMHSYLGSDDVQYAPSTLDWLT 241
                             :|::| :|||||.||...:::...:.:..:::.:.:....|...|.|.
Human   253 DLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLI 317

  Fly   242 GLITL------VTAAVF-----------GTVRLISSEM----------------------FSTAH 267
            ..:.|      |...|.           |.:||:..::                      |..|:
Human   318 SFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQAN 382

  Fly   268 ------FLDIC---EQHEVSWTIMANSHV------------------AMLANCPKTSAQKLRSLK 305
                  .||..   ::.|:...|:.|:.:                  .|:......||..|..|:
Human   383 TTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLR 447

  Fly   306 HLLFAGGHCLVATLKKMQSFLHGSGILRNAYGLTE--VGTLVSYNYDTQSKPTSVGRLMANIRVK 368
            ..|    .|         .|..|       ||.||  .|..::...|..:  ..||..|....:|
Human   448 AAL----GC---------QFYEG-------YGQTECTAGCCLTMPGDWTA--GHVGAPMPCNLIK 490

  Fly   369 IVD-SSGQLQGPKGLGEILCHNGQPWSGYVGNPLATAEMRDSAGWYHTGDVGYFDEDHYLHIVER 432
            :|| ........:|.||:.......:.||:.:|..|||..|..||.||||:|.:..:..|.|::|
Human   491 LVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDR 555

  Fly   433 KKDMLKYL-GMMYYPHEVEEVIAQMPDVAEVCVFG 466
            ||.:.|.. |....|.::|.:..:...||:|.|.|
Human   556 KKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHG 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11391	NP_650830.1	CaiC	24..541	CDD:223395	115/543 (21%)
CG11391	NP_650830.1	AFD_class_I	51..527	CDD:302604	110/515 (21%)
ACSL1	NP_001273637.1	LC-FACS_euk	116..694	CDD:341250	110/518 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930