DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11659 and CMR2

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_014736.1	Gene:	CMR2 / 854260	SGDID:	S000005619	Length:	1648	Species:	Saccharomyces cerevisiae

Alignment Length:	757	Identity:	130/757 - (17%)
Similarity:	239/757 - (31%)	Gaps:	279/757 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPYTP-----ENSYDNDQKIWSGEPVV-----KYFDPDLSIGEIIFHEMRRHPQLTAQISAT--- 52
            :|..|     ||:...|..:....|::     :::|     |:            ||.||..
Yeast   140 IPLLPRHTGAENTSSGDSAMTDSLPLILRGRFEHYD-----GQ------------TAMISINSKG 187

  Fly    53 EGTVLTRGELLANAMRLASYMRSLGLLQSDIVGLIGRNTTHMLAVAYA---CFFNGIAFHSLNI- 113
            :.|.:|..:|...|.|:|..:....|.:.|.: |:..|...::....|   ||.:|:|...::.
Yeast   188 KETFITWDKLYLKAERVAHELNKSHLYKMDKI-LLWYNKNDVIEFTIALLGCFISGMAAVPVSFE 251

  Fly   114 TYDRDTIEKIYKVTRPSIIFCDG---DEFEKVRSATAELDVKIV--------------------- 154
            ||....|.:|.|||....:....   .:.:.:.|::....||:|
Yeast   252 TYSLREILEIIKVTNSKFVLISNACHRQLDNLYSSSNHSKVKLVKNDVFQQIKFVKTDDLGTYTK 316

  Fly   155 ---TMRNHPLDSIKIDEVVATPI--------EENFQPAKLEKGNDQTLAILCSSGTTGTP----- 203
               |.....:.:|...|...||:        :.|....:.|     |:..:.:|  ...|
Yeast   317 AKKTSPTFDIPNISYIEFTRTPLGRLSGVVMKHNILINQFE-----TMTKILNS--RSMPHWKQK 374

  Fly   204 ---------KAVTITNSRHILAGNYHLTTADVQYSHNTLDWITGLLTTITSGVFSTTRIIA-DNA 258
                     |.:..||||.::..:...|.:            |||:..:...:|:...:|: |::
Yeast   375 SQSIRKPFHKKIMATNSRFVILNSLDPTRS------------TGLIMGVLFNLFTGNLMISIDSS 427

  Fly   259 F--DPAFALRIIEEYK---------------VTWTIQPPSSM------------ALMINCPDFET 294
            .  .|.....||::::               :.:...|.|:.            :.:.:|...:|
Yeast   428 ILQRPGGYENIIDKFRADILLNDQLQLKQVVINYLENPESAFSKKHKIDFSCIKSCLTSCTTIDT 492

  Fly   295 CDLSSL---------------RCYM-------FGGSRAALEVQKG-------------IRSRLSH 324
             |:|.:               .||.       |||...::..|.|             :::.|..
Yeast   493 -DVSEMVVHKWLKNLGCIDAPFCYSPMLTLLDFGGIFISIRDQLGNLENFPIHNSKLRLQNELFI 556

  Fly   325 NCLQFVYGFTELGAMATIN--CHFDE--KTGSVGQLVNGLKMKIKNDDGESLGPD-EIGEVCIMN 384
            |..:......|....|.||  ..|.:  |..:.|..:..:.:.:.|.|..:|..| .:||:.|.:
Yeast   557 NREKLKLNEVECSITAMINSSSSFKDYLKLETFGFPIPDITLCVVNPDTNTLVQDLTVGEIWISS 621

  Fly   385 NQ--------------------------HWSGYY--GNE-----------------VETRNMRDS 404
            |.                          .|:.|.  .||                 ..|..||..
Yeast   622 NHITDEFYQMDKVNEFVFKAKLNYSEMFSWAKYEMPTNEKSQAVTEQLDTILNICPANTYFMRTK 686

  Fly   405 L-GWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPN-------------------------- 442
            | |:.|:|.         :|::...::|.....::..||
Yeast   687 LMGFVHNGK---------IYVLSLIEDMFLQNRLIRLPNWAHTSNLLYAKKGNQSAQPKGNTGAE 742

  Fly   443 -----DIESVISE-------------MPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVV 489
                 ||.|:..|             :.|:.|..|..: :.:|  |.||..::....|.....||
Yeast   743 STKAIDISSLSGETSSGYKRVVESHYLQQITETVVRTV-NTVF--EVAAFELQHHKEEHFLVMVV 804

  Fly   490 DYVRSRTDSKYKQLNGGAVIVDDLQRSANGKTNRMANKAHFL 531
            :...::|:.:.|   .|......|.:.|..:.|::..|.:.|
Yeast   805 ESSLAKTEEESK---NGETTDTTLMKFAETQRNKLETKMNDL 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	121/712 (17%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	118/690 (17%)
CMR2	NP_014736.1	DMAP_binding	5..121	CDD:368923
		AFD_class_I	179..893	CDD:418409	121/701 (17%)
		Dip2	1004..1626	CDD:341231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810