DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11659 and ACSF2

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001275897.1	Gene:	ACSF2 / 80221	HGNCID:	26101	Length:	640	Species:	Homo sapiens

Alignment Length:	544	Identity:	132/544 - (24%)
Similarity:	234/544 - (43%)	Gaps:	64/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASYMRSLGLLQSDIVGLIGRNTTHM 94
            ::|:.:....:|.|:..|.:...|...||..:|.....:.||.:.|:||.:.|.:|:.|.|:...
Human    98 TVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAW 162

  Fly    95 LAVAYACFFNGIAFHSLNITYDRDTIEKIY-KVTRPSIIF----------------CDGDEFEKV 142
            :.:..|....||...|:|..|....:|.:. ||...:::|                |  .|.|..
Human   163 VLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQIC--PEVENA 225

  Fly   143 RSATAEL----DVKIVTMRNHPL-DSIKIDEVVATPIEENFQPAKLEKGNDQTLA------ILCS 196
            :....:.    |:..|...:.|| .::.:|||||.  ....|.....:.|.|.|:      |..:
Human   226 QPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAA--GSTRQHLDQLQYNQQFLSCHDPINIQFT 288

  Fly   197 SGTTGTPKAVTITNSRHILAGNYHLTTADVQYSHNTLDWITGLLT------------TITSGVFS 249
            |||||:||..|:  |.:.:..|.::....::....|.:.:..:|.            |:...::.
Human   289 SGTTGSPKGATL--SHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYG 351

  Fly   250 TTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDLSSLRCYMFGGSRAALEV 314
            .|.|:|...|:...||..|...:.|:....|:....::|.|||.:.|:|::...:..||.|..|:
Human   352 ATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPEL 416

  Fly   315 QKGIRSRLSHNCLQFVYGFTELGAMATINCHF-----DEKTGSVGQLVNGLKMKIKNDDGESLGP 374
            .:.|.::::...|...||.||...:..  .||     ::|..|||:::...:.:|.|.:..:|..
Human   417 IRAIINKINMKDLVVAYGTTENSPVTF--AHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAK 479

  Fly   375 -DEIGEVCIMNNQHWSGYYGNEVETRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIM 438
             :..||:||.......||:|...:|....|...||.:||:..|:..||..|:.|.|:|:......
Human   480 LNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGEN 544

  Fly   439 YYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTD----SK 499
            .||.::|......|:|.||.|.|:..:..|:|..|.:..|.|.|...:::..:.:.:..    .|
Human   545 IYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPK 609

  Fly   500 YKQLNGGAVIVDDLQRSANGKTNR 523
            |      .|.|.:...:.:||..:
Human   610 Y------IVFVTNYPLTISGKIQK 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	132/542 (24%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	129/524 (25%)
ACSF2	NP_001275897.1	PRK08315	82..640	CDD:236236	132/544 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760