DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11659 and CG18586

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	300/531 - (56%)
Similarity:	398/531 - (74%)	Gaps:	2/531 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASY 72
            :||:..|||||......|.|:||||||||.:|..:|:|.||||.||..||||.:|..||||:|||
  Fly    16 TYDDKLKIWSGREAPSLFSPNLSIGEIIFGDMVNNPKLIAQISITEDIVLTREDLHMNAMRVASY 80

  Fly    73 MRSLGLLQSDIVGLIGRNTTHMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTRPSIIFCDGD 137
            ||::||.|:||||::||:|||..||||||||||...|:|:..|:...|.|::.:|:|.:||||||
  Fly    81 MRNMGLGQTDIVGVMGRHTTHQSAVAYACFFNGTPLHALHNAYEEACIAKLFGITKPRLIFCDGD 145

  Fly   138 EFEKVRSATAELDVKIVTMRNHPLDSIKIDEVVATPIEENFQPAKLEKGNDQTLAILCSSGTTGT 202
            |:|||:|||.:|.|.||||||||..|::|.:|:.||:.:||||.:|:.|.|.|||||.||||:|.
  Fly   146 EYEKVKSATKDLQVTIVTMRNHPRGSVRIQDVLTTPVMQNFQPLRLKDGIDHTLAILSSSGTSGF 210

  Fly   203 PKAVTITNSRHILAGNYHLTTADVQYSHNTLDWITGLLTTITSGVFSTTRIIADNAFDPAFALRI 267
            ||||||:||..|:.....:..:::||:.:||||.:||...|||||||||.||||..|||....|.
  Fly   211 PKAVTISNSHKIIVDYMAINNSNIQYTSSTLDWCSGLSMAITSGVFSTTSIIADCDFDPGLFCRA 275

  Fly   268 IEEYKVTWTIQPPSSMALMINCPDFETCDLSSLRCYMFGGSRAALEVQKGIRSRLSHNCLQFVYG 332
            |.:|:::..:...|.:|:..|||:||:.|||||...:||||..:||||:.:||||||:||.|.||
  Fly   276 IGKYRISMVLLSSSYLAIFANCPEFESADLSSLNYVIFGGSSCSLEVQRKVRSRLSHDCLNFCYG 340

  Fly   333 FTELGAMATINCHFDEKTGSVGQLVNGLKMKIKNDDGESLGPDEIGEVCIMNNQHWSGYYGNEVE 397
            .|||.:..::|.:||||..|||:.:.|:|:|:.::.||:..|:.:||:|..|:|.|:|||.|..|
  Fly   341 LTELNSAGSVNLNFDEKPNSVGRAIRGIKIKVIDEQGEAQEPNVVGEICFHNSQKWAGYYKNPDE 405

  Fly   398 TRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPNDIESVISEMPQVAEVCVFGI 462
            ||.::||..|.|:|||||:|:||:|:::||.|:|||||||||||::||:||:|||.|.|.|||||
  Fly   406 TRQIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPNVLEACVFGI 470

  Fly   463 WSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAVIVDDLQRSANGKTNRMANK 527
            |..:.||||||::|||.|::|||||||:|||.|..:|:|||||||:|||.:.||.|.||||.|.|
  Fly   471 WDPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFKQLNGGALIVDQIVRSGNRKTNRSAVK 535

  Fly   528 AHFLHLKNRKN 538
            .||  |||..|
  Fly   536 EHF--LKNYNN 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	282/496 (57%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	269/474 (57%)
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	289/507 (57%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	269/474 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471288
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I5187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	11	10.910