DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11659 and ACSM2B

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001098539.1	Gene:	ACSM2B / 348158	HGNCID:	30931	Length:	577	Species:	Homo sapiens

Alignment Length:	502	Identity:	111/502 - (22%)
Similarity:	203/502 - (40%)	Gaps:	46/502 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ELLANAMRLASYMR-SLGLLQSDIVGLIGRNTTHMLAVAYACFFNGIAFHSLNITY-DRDTIEKI 123
            ||..|:.:.|:.:. :.||.:.|.|.::.........|...|...|:.|....|.. ..|.:.::
Human    85 ELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRL 149

  Fly   124 YKVTRPSIIFCDG--DEFEKVRSATAELDVKIVTMRNHPLDSIKIDEVVATPIEENFQPAKLEKG 186
            ......:|:..|.  .|.:.|.|....|.:|::.........:...:::.   |.:.....:|.|
Human   150 QMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLN---EASTTHHCVETG 211

  Fly   187 NDQTLAILCSSGTTGTPKAVTITNSRHIL-----AGNYHLTTADVQYSHNTLDWITGLLTTI--- 243
            :.:..||..:|||:|.||....:.|...|     ||...|..:|:.::.:...||..:|.::
Human   212 SQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILGSLLES 276

  Fly   244 -TSGVFSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDLSSLRCYMFGG 307
             |.|..:...::.  .|||...|:.:..|.:...:..|....:::. .|..:.....|:..:.||
Human   277 WTLGACTFVHLLP--KFDPLVILKTLSSYPIKSMMGAPIVYRMLLQ-QDLSSYKFPHLQNCLAGG 338

  Fly   308 SRAALEVQKGIRSRLSHNCLQFVYGFTELGAMATINCHFDEKTGSVGQLVNGLKMKIKNDDGESL 372
            .....|..:..|::...:..:| ||.||.|....::.....|.|.:|...:...:::.:|.|..|
Human   339 ESLLPETLENWRAQTGLDIREF-YGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVL 402

  Fly   373 GPDEIGEVCIMNNQ-----HWSGYYGNEVET-RNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEM 431
            .|...|::.|....     .:|||..|..:| .|:|... |. .||.|..|.||:...|.|..::
Human   403 PPGTEGDIGIRVKPIRPIGIFSGYVENPDKTAANIRGDF-WL-LGDRGIKDEDGYFQFMGRADDI 465

  Fly   432 LKYQNIMYYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQD-------VV 489
            :........|:::|:.:.:.|.|.|..|......:.|:...|.|:  |.|:..:.|       :.
Human   466 INSSGYRIGPSEVENALMKHPAVVETAVISSPDPVRGEVVKAFVI--LASQFLSHDPEQLTKELQ 528

  Fly   490 DYVRSRTDSKYKQ-------LNGGAVIVDDLQRS-ANGKTNRMANKA 528
            .:|:|.| :.||.       ||....:...:||: ...|..:|:.||
Human   529 QHVKSVT-APYKYPRKIEFVLNLPKTVTGKIQRTKLRDKEWKMSGKA 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	108/495 (22%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	108/494 (22%)
ACSM2B	NP_001098539.1	AFD_class_I	40..568	CDD:388389	108/494 (22%)
		Coenzyme A binding. /evidence=ECO:0000250	469..471		0/1 (0%)
		Coenzyme A binding. /evidence=ECO:0000250	540..542		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920