DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11659 and DIP2

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_612019.2	Gene:	DIP2 / 252479	FlyBaseID:	FBgn0024806	Length:	1773	Species:	Drosophila melanogaster

Alignment Length:	687	Identity:	134/687 - (19%)
Similarity:	243/687 - (35%)	Gaps:	214/687 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DLSIGEIIFHEMRRHPQLTAQISA----------------TEGTV---LTRGELLANAMRLASYM 73
            |:.:.|    :..|.|||...:..                ::|.:   ||..||...|.::|:.:
  Fly  1124 DVGLAE----DCERKPQLITGVLRWRANTSPDHIIFTLLNSKGAIAKTLTCSELHKRAEKIAALL 1184

  Fly    74 RSLGLLQ-SDIVGLIGRNTTHMLAVAYACFFNG---IAF---HSLNITYDRDTIEKIYKVTRPSI 131
            :..|.:: .|.|.||......:|...|.|.:.|   |..   |..|:.....|:..|..|::..|
  Fly  1185 QERGRIEPGDHVALIFPPGLDLLCAFYGCLYLGAIPITIRPPHPQNLNTTLPTVRMIVDVSKSGI 1249

  Fly   132 IFCDGD--EFEKVRSATAELDVK----IVTMRNHPL------------DSIKIDEVVATPIEENF 178
            :.....  :..|.|.|...:|.|    |:.:.::|.            .|..:|..|:|
  Fly  1250 VLSIQPIIKLLKSREAATSIDPKTWPPILDIDDNPKRKYAGIATVSFDSSAYLDFSVST------ 1308

  Fly   179 QPAKLEKGN--DQTLAILCSSGTTGTPKAVTITNSRH--------------------ILAGNYHL 221
             ..:|...|  .::|:.||:|    ...|..:..|||                    :.:|::.:
  Fly  1309 -CGRLSGVNITHRSLSSLCAS----LKLACELYPSRHVALCLDPYCGLGFVMWTLIGVYSGHHSI 1368

  Fly   222 TTADVQYSHNTLDWIT--------------GLLTTITSGVFSTTRIIADNAFDPAFALRIIEEYK 272
            ..|..:...|...|::              |::...|..:.::...:.....|    ||.:....
  Fly  1369 LIAPYEVEANPSLWLSTLSQHRVRDTFCSYGVIELCTKALSNSIPSLKQRNID----LRCVRTCV 1429

  Fly   273 VTWTIQPPSSM---------ALMINCPDFET---CDLSSLRCYMFGGSRAALEVQKGIRSRLSHN 325
            |....:|...:         ||.:|.....|   |.::...|.....|..:.:|...:|: |.:|
  Fly  1430 VVAEERPRVQLTQQFCKLFQALGLNTRCVSTSFGCRVNPAICVQGASSAESAQVYVDMRA-LRNN 1493

  Fly   326 CLQFVYGFTELGAMATINCHFDEKTGSVGQLVNGLKMKIKNDDGES-LGPDEIGEVCIMNNQHWS 389
            .:..|    |.||..:: |..:.     |:|:.|:|:.|.|.:.:. .|...:||:.:....:.:
  Fly  1494 RVALV----ERGAPNSL-CVIES-----GKLLPGVKVIIANPETKGHCGDSHLGEIWVQAPHNAN 1548

  Fly   390 GY---YGNEVETR---NMRDSLG-----WYHSGDLGYM--------------------DRDG--- 420
            ||   ||:|.:..   |.:...|     :..:|.||::                    .||.
  Fly  1549 GYFTIYGDETDYNDHFNAKLVTGATSELYARTGYLGFLRRTECSQSASLLDETTPSVASRDSDTE 1613

  Fly   421 ---------------------------------------FLYIMDRKKEMLKYQNIMYYPNDIE- 445
                                                   .:|::....|::..:.:.|:|.|||
  Fly  1614 SLNSISQLQLNFSNVSLGGNSEHSLVGGASNANDQELHDAVYVVGAVDEVISLRGMNYHPIDIEN 1678

  Fly   446 SVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAVIV 510
            ||:....::||..|| .|:|:.     ..||:..|:|.||.|:|..|.:.....::.:.|..|:|
  Fly  1679 SVMRCHKKIAECAVF-TWTNLL-----VVVVELDGNESEALDLVPLVTNTVLEDHQLIVGVVVVV 1737

  Fly   511 DD--LQRSANGKTNRMANKAHFLHLKNRKNILLSQIN 545
            |.  :..::.|:..||       ||  |...|..|::
  Fly  1738 DPGVVPINSRGEKQRM-------HL--RDGFLADQLD 1765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	127/663 (19%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	121/643 (19%)
DIP2	NP_612019.2	DMAP_binding	3..115	CDD:283995
		ARG80	33..369	CDD:227400
		PRK09192	470..1061	CDD:236403
		Dip2	470..1054	CDD:213273
		AMP-binding	1142..1587	CDD:278902	90/470 (19%)
		AFD_class_I	1159..1762	CDD:302604	127/643 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810