DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11659 and DIP2A

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_011527794.1	Gene:	DIP2A / 23181	HGNCID:	17217	Length:	1607	Species:	Homo sapiens

Alignment Length:	650	Identity:	148/650 - (22%)
Similarity:	246/650 - (37%)	Gaps:	175/650 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGEPVVKYFDPD-----LSIGEII---FHEMRRHPQLTAQISATEGTVLTRG---ELLANAMRLA 70
            ||..:....|.|     |.:.:::   .|....|| |...::| :|||.:..   :|...|.|:|
Human  1004 SGRELAHLEDSDQARKFLFLADVLQWRAHTTPDHP-LFLLLNA-KGTVTSTATCVQLHKRAERVA 1066

  Fly    71 SYMRSLGLLQ-SDIVGLIGRNTTHMLAVAYACFFNGIA------FHSLNITYDRDTIEKIYKVTR 128
            :.:...|.|. .|.|.|:......::|..|.|.:.|..      .|..|:.....|::.|.:|::
Human  1067 AALMEKGRLSVGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSK 1131

  Fly   129 PSIIFCDGDEFEKVRS--ATAELDVKIVTMRNHP--LDSIKIDEVVATPIEENFQPAKLEKGNDQ 189
            .:.:.........:||  |.|.:|:     |..|  ||:   |::....|...|:|.     :..
Human  1132 SACVLTTQAVTRLLRSKEAAAAVDI-----RTWPTILDT---DDIPKKKIASVFRPP-----SPD 1183

  Fly   190 TLAIL-CSSGTTGTPKAVTITNSRHILAGNYHLTTADVQYSHNT--------------------- 232
            .||.| .|..|||            ||||        |:.||..
Human  1184 VLAYLDFSVSTTG------------ILAG--------VKMSHAATSALCRSIKLQCELYPSRQIA 1228

  Fly   233 --LDWITGL------LTTITSGVFSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINC 289
              ||...||      |.::.||..|......:...:.:..|..:.:||...|.   .|.::|..|
Human  1229 ICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTF---CSYSVMEMC 1290

  Fly   290 PD----------FETCDLSSLR-CYMFGGSRAALEVQK---------GIRSRLSHN--------- 325
            ..          .:..:||.:| |.:....|..:.:.:         |:.:|....
Human  1291 TKGLGAQTGVLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKDLGLPARAVSTTFGCRVNVA 1355

  Fly   326 -CLQFVYG------FTELGAMATINCHFDEKTGS--------VGQLVNGLKMKIKNDDGES-LGP 374
             |||...|      :.::.|:........|: ||        .|:::.|:|:.|.:.:.:. ||.
Human  1356 ICLQGTAGPDPTTVYVDMRALRHDRVRLVER-GSPHSLPLMESGKILPGVKVIIAHTETKGPLGD 1419

  Fly   375 DEIGEVCIMNNQHWSGY---YGNE---VETRNMRDSLG-----WYHSGDLGYM----------DR 418
            ..:||:.:.:..:.:||   ||.|   .:..:.|.|.|     |..:|.||::          .|
Human  1420 SHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGGR 1484

  Fly   419 DGFLYIMDRKKEMLKYQNIMYYPNDIE-SVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSE 482
            ...||::....|.|:.:.:.|:|.||| |||.....:||..|| .|:|:.     ..||:..|.|
Human  1485 HDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVF-TWTNLL-----VVVVELDGLE 1543

  Fly   483 LEAQDVVDYVRSRTDSKYKQLNGGAVIVDD--LQRSANGKTNRMANKAHFLHLKNRKNILLSQIN 545
            .:|.|:|..|.:....::..:.|..||||.  :..::.|:..||       ||  |...|..|::
Human  1544 QDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRM-------HL--RDGFLADQLD 1599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	139/617 (23%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	132/587 (22%)
DIP2A	XP_011527794.1	DMAP_binding	9..158	CDD:283995
		CaiC	360..959	CDD:223395
		AFD_class_I	392..956	CDD:302604
		AMP-binding	1027..1501	CDD:278902	108/512 (21%)
		AFD_class_I	1044..1596	CDD:302604	138/604 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810