DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11659 and DIP2C

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_011517730.1	Gene:	DIP2C / 22982	HGNCID:	29150	Length:	1626	Species:	Homo sapiens

Alignment Length:	662	Identity:	159/662 - (24%)
Similarity:	248/662 - (37%)	Gaps:	191/662 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHP-QLTAQISATEGTV---LTRGELLANAMRLA 70
            ||||        .:.|   |.:.|::....:..| .:...:....|.:   ||..:|...|.::|
Human  1022 DNDQ--------ARKF---LFLSEVLQWRAQTTPDHILYTLLNCRGAIANSLTCVQLHKRAEKIA 1075

  Fly    71 SYMRSLGLLQ-SDIVGLIGRNTTHMLAVAYACFFNGIA------FHSLNITYDRDTIEKIYKVTR 128
            ..:...|.|| .|.|.|:......::|..|.|.:.|..      .|..||.....|::.|.:|:|
Human  1076 VMLMERGHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSR 1140

  Fly   129 PSI-----IFCDGDEFEKVRSATAELDVKIVTMRNHPLDSIKIDEVVATPIEENFQPAKLEKG-N 187
            .:.     :.|   :..:.|.|.|.:||     |..||       ::.|......:||::.|. |
Human  1141 SACLMTTQLIC---KLLRSREAAAAVDV-----RTWPL-------ILDTDDLPKKRPAQICKPCN 1190

  Fly   188 DQTLAIL-CSSGTTGTPKAVTITNSRHILAGNYHLTTADVQYSHNT------------------- 232
            ..|||.| .|..|||            :|||        |:.||..
Human  1191 PDTLAYLDFSVSTTG------------MLAG--------VKMSHAATSAFCRSIKLQCELYPSRE 1235

  Fly   233 ----LDWITGL------LTTITSGVFSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMI 287
                ||...||      |.::.||..|.....::...:||..|..:.:|||..|....|.|.|..
Human  1236 VAICLDPYCGLGFVLWCLCSVYSGHQSILIPPSELETNPALWLLAVSQYKVRDTFCSYSVMELCT 1300

  Fly   288 NCPDFET-------CDLSSLR-CYMFGGSR--------------------AALEVQKGIRSRLSH 324
            .....:|       .|||.:| |.:....|                    .|:....|.|..|:
Human  1301 KGLGSQTESLKARGLDLSRVRTCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLA- 1364

  Fly   325 NCLQ------------------FVYGFTELGAMATINCHFDEKTGS--------VGQLVNGLKMK 363
            .|||                  .||  .::.|:........|: ||        .|:::.|:::.
Human  1365 ICLQPHRLWTLAEQGTSGPDPTTVY--VDMRALRHDRVRLVER-GSPHSLPLMESGKILPGVRII 1426

  Fly   364 IKNDDGES-LGPDEIGEVCIMNNQHWSGY---YGNE---VETRNMRDSLG-----WYHSGDLGYM 416
            |.|.:.:. ||...:||:.:.:..:.|||   ||:|   .:..|.|.|.|     |..:|.||::
Human  1427 IANPETKGPLGDSHLGEIWVHSAHNASGYFTIYGDESLQSDHFNSRLSFGDTQTIWARTGYLGFL 1491

  Fly   417 ----------DRDGFLYIMDRKKEMLKYQNIMYYPNDIE-SVISEMPQVAEVCVFGIWSNIFGDE 470
                      :|...||::....|.::.:.:.|:|.||| |||.....|.|..|| .|:|:.
Human  1492 RRTELTDANGERHDALYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVF-TWTNLL--- 1552

  Fly   471 AAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAVIVD--DLQRSANGKTNRMANKAHFLHL 533
              ..||:..|||.||.|:|..|.:....::..:.|..|:||  .:..::.|:..||       ||
Human  1553 --VVVVELDGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDIGVIPINSRGEKQRM-------HL 1608

  Fly   534 KNRKNILLSQIN 545
              |...|..|::
Human  1609 --RDGFLADQLD 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	147/622 (24%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	144/599 (24%)
DIP2C	XP_011517730.1	DMAP_binding	<32..180	CDD:283995
		CaiC	377..968	CDD:223395
		Dip2	401..965	CDD:213273
		AMP-binding	1036..1520	CDD:278902	116/522 (22%)
		AFD_class_I	1053..1615	CDD:302604	150/615 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810