DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11659 and ACSL4

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	XP_024308119.1	Gene:	ACSL4 / 2182	HGNCID:	3571	Length:	717	Species:	Homo sapiens

Alignment Length:	691	Identity:	135/691 - (19%)
Similarity:	250/691 - (36%)	Gaps:	209/691 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PYTPENSYDN----DQKIWSGEPVVKYFD---------PDLSIGEIIFHEMRRHPQLTAQISATE 53
            ||.....:|:    |  |...:.:.|.||         ..|...||:..|....|         .
Human    64 PYRSVTHFDSLAVID--IPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQP---------N 117

  Fly    54 GTVLTRGELLANAMRLASYMR-------------SLGLLQSDIVGLIGRNTTHMLAVAYACFFNG 105
            |.|..:  |:....:..:|:.             :|||...:.:.:........:..|..||...
Human   118 GKVFKK--LILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYN 180

  Fly   106 IAFHSLNITYDRDTI-------EKIYKVTRPSIIFCDGDEFEKVRSATAEL---------DVKIV 154
            ....:|..|..::.:       |..|.:|...::      ..|:::|..::         |.|.:
Human   181 FPLVTLYATLGKEAVVHGLNESEASYLITSVELL------ESKLKTALLDISCVKHIIYVDNKAI 239

  Fly   155 TMRNHP----LDSIK-IDEVVATPIEENFQPAKLEKGNDQTLAILCSSGTTGTPKAVTITNSRHI 214
            ....:|    :.|:: ::|:.:.|......|:: ...:|..: ::.:||:||.||.|.:.:| ::
Human   240 NKAEYPEGFEIHSMQSVEELGSNPENLGIPPSR-PTPSDMAI-VMYTSGSTGRPKGVMMHHS-NL 301

  Fly   215 LAG---------------NY--HLTTADVQYSHNTLDWITGLLTTITSGV---FSTTRIIADNAF 259
            :||               .|  :|..|.|      |: :|..::..|.|.   :|:...::|.
Human   302 IAGMTGQCERIPGLGPKDTYIGYLPLAHV------LE-LTAEISCFTYGCRIGYSSPLTLSDQ-- 357

  Fly   260 DPAFALRIIEEYKVTWTIQPPSSMALMINCPD-------FETCDLSSLRCYMF--GGSRAALEVQ 315
                :.:|.:..|...|:..|:.||.:....|       .:..:::.::..:|  |......:::
Human   358 ----SSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIK 418

  Fly   316 KG---------------------IRSRLS---------HNCLQFV--------YGFTELGAMATI 342
            ||                     :|..||         |..:...        ||.||.....|:
Human   419 KGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTV 483

  Fly   343 NCHFDEKTGSVGQLVNGLKMKIKN--DDGESLG--PDEIGEVCIMNNQHWSGYYGNEVETRN--M 401
            ....|..||.||..:...::|:|:  :.|.::.  |:..||:.|.......||:.||.:|..  .
Human   484 TEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYS 548

  Fly   402 RDSLG--WYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYP-NDIESVISEMPQVAEVCVF--- 460
            .|..|  |:.:||:|....||.|.|:||||:::|.|...|.. ..:|:.:...|.:..:|.|
Human   549 VDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKS 613

  Fly   461 --------------------------GIWSNIFGDEA-AAAVVKKL-----GSELEAQDVVDYVR 493
                                      |.|.:|..:.| .|.::|::     ..:||..::...||
Human   614 DQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVR 678

  Fly   494 SR-----------TDS---KYKQLNGGAVIVDDLQRSANGK 520
            ..           ||:   |.|:|...  .:.|::|...||
Human   679 LSPEPWTPETGLVTDAFKLKRKELRNH--YLKDIERMYGGK 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	128/663 (19%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	122/633 (19%)
ACSL4	XP_024308119.1	LC-FACS_euk	127..714	CDD:213293	117/610 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148964
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930