DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11659 and acs-1

DIOPT Version :9

Sequence 1:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_001023937.1	Gene:	acs-1 / 179043	WormBaseID:	WBGene00018488	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	131/564 - (23%)
Similarity:	226/564 - (40%)	Gaps:	94/564 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASYMRSLGLLQSDIVGLIGRNTTHM 94
            ::|:.:...:.:.|.....|...||...|..::..:|..||..:..|||.:.|.:|:.|.||...
Worm    67 TVGDRLRSAVDQVPDKEFLIFKREGIRKTYSQVATDAENLACGLLHLGLKKGDRIGIWGPNTYEW 131

  Fly    95 LAVAYACFFNGIAFHSLNITYD----RDTIEKI---YKVTRPSIIFCDGDEFEKVRSATAELDVK 152
            ....:|....|:...::|.:|.    |..|||:   ..:|.|.  |...:.::.::....|:.:|
Worm   132 TTTQFASALAGMVLVNINPSYQSEELRYAIEKVGIRALITPPG--FKKSNYYQSIKDILPEVTLK 194

  Fly   153 I-----VTMRN-----HPL-----DSI-----KIDEVVATPIEEN-FQPAKLEKGN--DQTLAIL 194
            .     :|.||     |.:     |.|     |..:|:....||: ...:|:|:..  |.:|.|.
Worm   195 EPGKSGITSRNFTCFQHLIMFDEEDKIYPGAWKYTDVMKMGTEEDRHHLSKIERETQPDDSLNIQ 259

  Fly   195 CSSGTTGTPKAVTITNSRHILAGNYHLTTADVQYS------------HNTLDWITGLLTTITSGV 247
            .:|||||.||..|:|:  |.:..|.........||            ::....:.|:|..:|
Worm   260 YTSGTTGQPKGATLTH--HNVLNNAFFVGLRAGYSEKKTIICIPNPLYHCFGCVMGVLAALT--- 319

  Fly   248 FSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDLSSLRCYMFGGSRAAL 312
            ...|.:....:||...||:.|.|.|.|.....|:....|||.|::...:..|:|.....|:...:
Worm   320 HLQTCVFPAPSFDALAALQAIHEEKCTALYGTPTMFIDMINHPEYANYNYDSIRSGFIAGAPCPI 384

  Fly   313 EVQKGIRSRLSHNCLQFVYGFTELGAMATINCHFD---EKTGSVGQLVNGLKMKIKNDDGESLGP 374
            .:.:.:...:....:|..||.||...::.::...|   ::..|||.:::.|:..|. |....:.|
Worm   385 TLCRRLVQDMHMTDMQVCYGTTETSPVSFMSTRDDPPEQRIKSVGHIMDHLEAAIV-DKRNCIVP 448

  Fly   375 DEI-GEVCIMNNQHWSGYYGNEVETRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIM 438
            ..: |||.:........|:.:|.:|:.......|||:||:..|..:|.:.|:.|.|:|:......
Worm   449 RGVKGEVIVRGYSVMRCYWNSEEQTKKEITQDRWYHTGDIAVMHDNGTISIVGRSKDMIVRGGEN 513

  Fly   439 YYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQL 503
            .||.::|..:.:...|.:|.:.|:....||:...|                 :||
Worm   514 IYPTEVEQFLFKHQSVEDVHIVGVPDERFGEVVCA-----------------WVR---------- 551

  Fly   504 NGGAVIVDDLQRSANGKTNRMANKA----HFLHLKNRKNILLSQ 543
                     |..||.|||.....||    ...|.|..:.||..:
Worm   552 ---------LHESAEGKTTEEDIKAWCKGKIAHFKIPRYILFKK 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	125/538 (23%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	122/520 (23%)
acs-1	NP_001023937.1	PRK08315	53..615	CDD:236236	131/564 (23%)
acs-1	NP_001023937.1	FACL_like_2	252..604	CDD:213284	89/377 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860