DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6300 and acsf2

DIOPT Version :9

Sequence 1:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001038884.2	Gene:	acsf2 / 751707	ZFINID:	ZDB-GENE-060825-7	Length:	606	Species:	Danio rerio

Alignment Length:	535	Identity:	125/535 - (23%)
Similarity:	220/535 - (41%)	Gaps:	67/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 MRRHPQLTAQISATEGTVLTRGELLANAMRLASYMRSLGLLQSDIVGIIGRNTTHMLAVAYACFF 103
            :.|:|...|.:...:|...|..|...:..:.|:.:.:.||.:.|.:|:.|.|....:.:.:|...
Zfish    76 VERYPDREAMVFVQDGIRKTFAEFYQDVEKAAAGLLAAGLKRGDRLGMWGPNIYEWVLMQFATAK 140

  Fly   104 NGIAFHSLNITYDRDTIE-KIYKVTRPSII---------FCD-----GDEFEKV------RSATA 147
            .||...::|..|....:| .:.||...:::         :||     ..|.|..      .|...
Zfish   141 AGIILVAVNPAYQLQEVEFALRKVQCNAVVCPTKFKSQHYCDMLKQLCPEMETASPGGIKSSRLP 205

  Fly   148 ELDVKIVTMRNHPLDSIKIDEVVATPIEENFQPAK-LEKG--NDQTLAILCSSGTTGTPKAVTIT 209
            :|...|||....| .|..:.:::.....:::|..: |:|.  .|..:.|..:|||||.||..|:
Zfish   206 DLHTVIVTDSQQP-GSFLLKDLMQAGSSQHYQQLQDLQKKLVCDDPINIQFTSGTTGKPKGATL- 268

  Fly   210 NSRHILAGNYHLTTADVQYSHNTLDW-----------ITGLLTTITSGV----FSTTRIIADNAF 259
             |.|.:..|.:.|...:.|     :|           :.....::..||    :.||.|.....:
Zfish   269 -SHHNIVNNAYFTGMRIGY-----NWRKNVRICLPVPLYHCFGSVGGGVIMALYGTTVIFPSTGY 327

  Fly   260 DPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDMSSLRCYMFGGSRAALEVQKGIRSRLSH 324
            |....||.||:.|.|:....|:....|:..||....|:||:|..:..||....||.:.|.:.:..
Zfish   328 DGRANLRAIEKEKCTFVYGTPTMYIDMLGQPDLAKFDLSSVRGGIAAGSPCPPEVMRKILNVMGI 392

  Fly   325 DCLQFVYGFTELGAMATINCHF-----DEKTGSVGQLVNGLKMKIIN-DDGESLGPDEIGEV--- 380
            ..:...||.||...:..  |.|     :.|..:||.:....:.|::: ..||.:.....||:
Zfish   393 KEMVIGYGTTENSPVTF--CGFPVDSAERKIETVGCISPHTEAKVVDPTTGEIVPLGAQGELMIR 455

  Fly   381 --CIMNNQHWSGYYGNEVETRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPND 443
              |:|..     |:.:|.:||.......||.:||:..:|:..:..|..|.|:::.......||.:
Zfish   456 GYCVMLE-----YWQDEEKTRECITKDRWYKTGDIASLDQFAYCKIEGRIKDLIIRGGENIYPAE 515

  Fly   444 IESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAV 508
            ||..:...|::.|..|.|:.....|:|..|.:..|.|.|...:::..|.:.:. :.|| :....:
Zfish   516 IEQFLHTHPKILEAQVVGVKDERMGEEVCACIRLKEGQECTVEEIKAYCKGKI-AHYK-VPRYIL 578

  Fly   509 IVDDLQRSANGKTNR 523
            .|.|...:..||..:
Zfish   579 FVQDYPLTITGKIQK 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	125/533 (23%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	123/524 (23%)
acsf2	NP_001038884.2	PRK08315	53..606	CDD:236236	125/535 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810