DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6300 and Acsf2

DIOPT Version :9

Sequence 1:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	145/560 - (25%)
Similarity:	238/560 - (42%)	Gaps:	73/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASYMRSLGLLQSDIVGIIGRNTTHM 94
            ::||.:....:|.|...|.:...|...|...:|.....|.||.:.|:||.:.|.:|:.|.|:...
  Rat    73 TVGECLDATAQRFPNREALVIIHENIRLNFAQLKEEVDRAASGLLSIGLRKGDRLGMWGPNSYAW 137

  Fly    95 LAVAYACFFNGIAFHSLNITYDRDTIEKIY-KVTRPSIIF----------------CDGDEFEKV 142
            :.:..|....||...|:|..|....:|.:. ||....|:|                |  .|.||.
  Rat   138 VLIQLATAQAGIILVSVNPAYQASELEYVLRKVGCKGIVFPKQFKTQQYYNILKQVC--PELEKA 200

  Fly   143 RSATAEL----DVKIVTMRNHPL-DSIKIDEVVATPIEENFQPAKLEKGNDQTLAIL-------- 194
            :....:.    |:..|...:.|| .::.:|||||.            .|.:|.||.|
  Rat   201 QPGALKSERLPDLTTVISVDAPLPGTLLLDEVVAA------------GGKEQNLAQLRYHQGFLS 253

  Fly   195 C--------SSGTTGTPKAVTITNSRHILAGNYHLTTADVQYSHNTLDWITGLLT---------- 241
            |        :|||||.||..|:  |.|.:..|.:|....::....|.:.:..:|.
  Rat   254 CYDPINIQFTSGTTGNPKGATL--SHHNIVNNSNLIGQRLKMPAKTAEELRMVLPCPLYHCLGSV 316

  Fly   242 --TITSGVFSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDMSSLRCYM 304
              |:.|.|...|.:::..:|:...||..|...|.|.....|:....::|.|||.:.|.:::|..:
  Rat   317 GGTMVSVVHGATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTTIRGGV 381

  Fly   305 FGGSRAALEVQKGIRSRLSHDCLQFVYGFTELGAMATINCHFD---EKTGSVGQLVNGLKMKIIN 366
            ..||.|..|:.:.|.|:::...|..|||.||...:..:|...|   :|.||||:::...:.:|:|
  Rat   382 IAGSLAPPELIRAIISKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVN 446

  Fly   367 -DDGESLGPDEIGEVCIMNNQHWSGYYGNEVETRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKE 430
             :.||....:..||:||.......||:|...:|........||.:||:..||..||..|:.|.|:
  Rat   447 METGELTKLNMPGELCIRGYCVMQGYWGEPQKTFETVGQDRWYRTGDIASMDEQGFCRIVGRSKD 511

  Fly   431 MLKYQNIMYYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSR 495
            |:.......||.::|....:.|||.|..|.|:..:..|:|..|.:..|.|.....:::..:.:.:
  Rat   512 MIIRGGENIYPAELEDFFHKHPQVQEAQVVGVKDDRMGEEICACIRLKSGETTTEEEIKAFCKGK 576

  Fly   496 TDSKYKQLNGGAVIVDDLQRSANGKTNRMANKAYF-LHLK 534
            . |.:| :....|.|:....:.:||..:...:... .|||
  Rat   577 I-SHFK-IPRYIVFVEGYPLTVSGKIQKFKLREQMEQHLK 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	142/546 (26%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	138/528 (26%)
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	145/560 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810