DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6300 and acsl4a

DIOPT Version :9

Sequence 1:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_956943.1	Gene:	acsl4a / 393622	ZFINID:	ZDB-GENE-040426-1565	Length:	706	Species:	Danio rerio

Alignment Length:	556	Identity:	120/556 - (21%)
Similarity:	204/556 - (36%)	Gaps:	158/556 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASY 72
            |.||:.     :|..|.| ..|.:||   ::.:.:.:|..::|                 ...|.
Zfish    99 SGDNET-----QPNGKVF-KKLILGE---YKWKSYEELDIEVS-----------------HFGSG 137

  Fly    73 MRSLGLLQSDIVGIIGRNTTHMLAVAYACF---FNGIAFHS----------LN---ITYDRDTIE 121
            :.:||......:.|........:..|.|||   |..:.|::          ||   :|:...:||
Zfish   138 LAALGQQPKSTIAIFCETRAEWMITAQACFRRNFPLVTFYATLGEDAVAYGLNESGVTHLVTSIE 202

  Fly   122 ----KIYKV-----TRPSIIFCDGDEFEKVRSATAELDVKIVTMRNHPLDSIKIDEVVATPIEEN 177
                |:..|     ....||:.|.   :.:.:|.....::|.:|.:       ::|:.|.|  ||
Zfish   203 LLETKLKSVLLQIPNLKHIIYVDS---KSMNTAGFPQGIQIHSMHS-------VEELGAKP--EN 255

  Fly   178 FQPAKLEKGNDQTLAILCSSGTTGTPKAVTITNSRHI--LAGNYH----LTTADVQYSHNTLDWI 236
            .....::........|:.:||:||.||.|.|.:|..|  :||...    |...|...::..|..:
Zfish   256 LNRPIVKPVPSDLAVIMYTSGSTGRPKGVMIIHSNLIGGMAGQCERIPGLGPKDTYIAYLPLAHV 320

  Fly   237 ---TGLLTTITSGV---FSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALM--------- 286
               |..::.:|.|.   :|:.:.::|.      :.:|.:..|...::..||.||.:
Zfish   321 LEMTAEISCVTYGCRIGYSSPQTLSDQ------STKIKKGSKGDCSVLKPSLMAAVPEIMDRINK 379

  Fly   287 --------INCP--------------------DFETCDM----------SSLRCYMFGGSRAALE 313
                    ::|.                    |...|::          .::|..:.||:..:..
Zfish   380 NVMSKVQEMSCVQRTLFKPAYDYKLEQIKKGYDAPLCNILFKKVRALLGGNVRMMLSGGAPLSPA 444

  Fly   314 VQKGIRSRLSHDCLQFV------YGFTELGAMATINCHFDEKTGSVGQ--LVNGLKMKIINDDGE 370
            .|     |..:.|  |.      ||.||.....||....|..||.||.  :...:|:|...:.|.
Zfish   445 TQ-----RFMNIC--FCCPVGQGYGLTETCGAGTITEVADYSTGRVGAPLICCEVKLKDWAEGGY 502

  Fly   371 SL--GPDEIGEVCIMNNQHWSGYYGNE--------VETRNMRDSLGWYHSGDLGYMDRDGFLYIM 425
            :.  .|...||:.|.......|||..|        |:....|    |:.:||:|.|..||.|.|:
Zfish   503 TKRDKPHPRGEILIGGPNVTMGYYRTEGCNNDDFFVDQNGQR----WFCTGDIGEMHADGCLQIV 563

  Fly   426 DRKKEMLKYQNIMYYP-NDIESVISEMPQVAEVCVF 460
            ||||:::|.|...|.. ..:||.:.....|..:|.:
Zfish   564 DRKKDLVKLQAGEYVSLGKVESALKNCSFVDNICAY 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	114/538 (21%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	110/517 (21%)
acsl4a	NP_956943.1	PLN02387	60..703	CDD:215217	120/556 (22%)
acsl4a	NP_956943.1	LC-FACS_euk	117..703	CDD:213293	113/532 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930