DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6300 and pdgy

DIOPT Version :9

Sequence 1:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	137/568 - (24%)
Similarity:	233/568 - (41%)	Gaps:	67/568 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YTPENSYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLT----RGELL 63
            |:||:.|   .|....:||.   .|::.:.|.::.:.::..:.||.:........|    |....
  Fly    55 YSPEDGY---YKTSPFDPVT---IPNVPLHEYVWRDFKKWERRTAAVCVITDRQYTFAQMRDASA 113

  Fly    64 ANAMRLASYMRSLGLLQSDIVGIIGRNTTHMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTR 128
            |.|:||.:   ...|.:.|::.|...|..............|:...::|..|..|.|.:....:.
  Fly   114 AFAVRLQT---KFNLQKPDVLAICLPNLPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSG 175

  Fly   129 PSIIFCDGDEFEKVRSATAEL--DVKIVTMRNH-----PLDSIKIDEVVATPIEENFQ----PAK 182
            ...:......|..:..|:..:  .:.|..:|..     |..:|...|:.:|   :|.:    .|.
  Fly   176 AKFLVGTVSGFATLSQASKLVGRQIPIAVVRTSAEEALPEGAIDFSELTST---QNVRYEDLKAP 237

  Fly   183 LEKGNDQTLAILCSSGTTGTPKAVTITNSRHILAGNYHLTTA----DVQYSHNTLD------WIT 237
            .|...|..:.:..||||||.||.|.::::.  :..|.....|    |:....|||.      .|.
  Fly   238 KEASADDMVFLPFSSGTTGLPKGVMLSHNN--ITSNCEQVQASLPLDLMGPQNTLPGVLPFFHIY 300

  Fly   238 GLLTTITSGVFSTTRIIADNAFDPAFALRIIEEYKVT-WTIQPPSSMALMINCPDFETCDMSSLR 301
            ||...:.|.:....|:.....|.|...:|.:::|:.: ..:.||.:: .|||.|.........|:
  Fly   301 GLTVVMLSKLGQGCRLATMPCFKPDDFMRSLDKYQGSILNLVPPIAL-FMINHPKLTQETAPHLK 364

  Fly   302 CYMFGGSRAALEVQKGIRSRLSHDCLQFV-----------YGFTELGAMATINCHFDEKTGSVGQ 355
            ..|.|.:...           .||..:|:           ||.||...:..:....::...|.|.
  Fly   365 VVMSGAAPIG-----------QHDVERFLNKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGV 418

  Fly   356 LVNGLKMKII---NDDGESLGPDEIGEVCIMNNQHWSGYYGNEVETRNMRDSLGWYHSGDLGYMD 417
            |....:.||:   ..|.:.:||...||:|:...|..:||..|:...:.......|..|||:.:.|
  Fly   419 LPASTEAKIVPLDGSDAKGVGPRTTGELCVRGPQVMAGYLNNDEANQVTFYPGNWLRSGDVAFYD 483

  Fly   418 RDGFLYIMDRKKEMLKYQNIMYYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSE 482
            .||..||.||.||::|.:.....|.::|:|:.:.|::.|..||||.....|:...|.||.:.|.:
  Fly   484 EDGLFYITDRMKELIKVKGFQVPPAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQGEK 548

  Fly   483 LEAQDVVDYVRSRTDSKYKQLNGGAVIVDDLQRSANGKTNRMANKAYF 530
            ..|:::..||..|. :.||:|.||.:.||::.::..||..|...|..|
  Fly   549 ASAEEISAYVAERV-AHYKKLEGGVIFVDEVPKNPTGKILRRELKEKF 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	127/536 (24%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	124/514 (24%)
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	128/538 (24%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	123/508 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850