DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6300 and acs-12

DIOPT Version :9

Sequence 1:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_508035.1	Gene:	acs-12 / 180375	WormBaseID:	WBGene00009106	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	124/519 - (23%)
Similarity:	220/519 - (42%)	Gaps:	46/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PDLSIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASYMRSLGLLQSDIVGIIGRNT 91
            ||.:..:.:|||..:..:..|.|........|..:::..|..:|..:..|.:.:|::|.::...:
Worm    13 PDKTFHDFLFHEWEKFREDVALIDNDTFAQFTFQDVMQKADFIAKSLVYLKVEKSEVVLLVMDWS 77

  Fly    92 THMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTRPSIIFCDG---DEFEKVRSATAELDVKI 153
            ...:.:|......|.|...::.......::...|.:....:|.|.   .|.:|:.. |...:.:|
Worm    78 PAAIYIALGASMAGAAIQVVSPKLQAWEMQFPVKESESRFVFSDPLGLHEIDKLMK-TLNREYRI 141

  Fly   154 VTMRNHPL-DSIKIDEVVATPIEENFQPAKLEKGNDQTLAILCSSGTTGTPKAVTITN------- 210
            :...:... :...|.|.:|...::|....|:|...| .:.:..|||..|..|.:..|:
Worm   142 ICTGSRDFANGYPIIEDLAFAAKQNLPLPKIEPDTD-IVYLPYSSGIHGKRKGIVTTHKVMVAKT 205

  Fly   211 ------SRH--ILAGNYHLTTADVQYSHNTLDWITGLLTTITSGVFSTTRIIADNAFDPAFALRI 267
                  |:|  ...|:..||...: :....||   .:|..:.:|:    .::.:..|.....:..
Worm   206 MVMWNTSKHHEFRRGDTTLTMIPL-HKQCGLD---AILCALLNGL----TVVTEKNFCVHTFMTC 262

  Fly   268 IEEYKVTWTIQPPSSMALMINCPDFETCDMSSLRCYMFGGSRAALEVQKGIRSRL-SHDCLQFVY 331
            |:.||:......|..|.||:...:..|.::.||...:.|......|:.:...... |...:...|
Worm   263 IQRYKIRAVHLTPYLMNLMMFEAENHTYNIESLEWVVTGADAVTEELYEEFTEIFPSVKTVTQTY 327

  Fly   332 GFTELGAMA-TINCHFDEKTGSVGQLVNGLKMKIIND-DGESLGPDEIGEVCIMNNQHWSGYYGN 394
            |.||:|.:. |.|.::   :.|.|||...|:||:::. .|:.|||.|.|::|:......|.|..|
Worm   328 GMTEVGLICRTYNKNY---SPSCGQLTANLEMKVLDILTGKELGPREKGQICVKGIAAESPYLNN 389

  Fly   395 EVET-RNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPNDIESVISEMPQVAEVC 458
            ...| .:..|  ||..:||:|:.|.:|.::::|:.|||:|.......|.:||:::.....|.|..
Worm   390 PKATEEHFLD--GWRRTGDIGFFDEEGNVHLVDKLKEMIKVFGYQVIPKEIETLLLTHQAVEEAA 452

  Fly   459 VFGIWSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQL---NGGAVIVDDLQRSANG 519
            |..|.:.:.|:...|.||.|.|......|:.|||..|. .:||.|   |    |...|.:||.|
Worm   453 VVAINNELSGERPVAFVVLKKGFVATEDDLKDYVNKRV-IRYKHLVRVN----ITQFLPKSACG 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	124/519 (24%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	119/499 (24%)
acs-12	NP_508035.1	PLN02246	2..518	CDD:215137	124/519 (24%)
acs-12	NP_508035.1	Firefly_Luc_like	33..514	CDD:213279	119/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920