DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6300 and acs-16

DIOPT Version :9

Sequence 1:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_490859.1	Gene:	acs-16 / 171714	WormBaseID:	WBGene00018579	Length:	569	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	120/563 - (21%)
Similarity:	225/563 - (39%)	Gaps:	86/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DQKIW----SGEPVVKYFDPD-LSIGEIIF--HEMRRHPQLTAQISATEGTVLTRGELLANAMRL 69
            |...|    |..|..|..|.| .:|.::|:  .||.|    .|.:..:|...||..::::....|
Worm    12 DYNGWVTGVSKAPPPKQIDFDSQTIPQLIYTKSEMDR----VAAVFDSEKLSLTFSKIVSEMESL 72

  Fly    70 ASYMRSLGLLQSDIVGIIGRNTTHMLAVAYACFFNGIAFHSLNITYDRD-TIEKIYKVTRPSIIF 133
            |:...|:||.|.|.|.:.|.|.:.::..|.||...|:.|...|..|... ::::..::.....|.
Worm    73 AAGFLSIGLKQGDRVLVAGSNHSQVMLCALACSRAGLVFSLANPNYPNSYSLKRALELGEFQCIV 137

  Fly   134 C------DGDEF---------EKVRSATAELDVKIVTMRNHPL---------DSIKIDEVVATPI 174
            |      :.|..         |.:||...:|..:::....|.:         .:..:.||.....
Worm   138 CFRAHQYEADHLNNLLLEIAPELMRSRKGQLKSELLPKLTHVILAEEDHKHAGTFTLSEVFLKSS 202

  Fly   175 EENFQPAKL---EKGNDQTLAIL-CSSGTTGTPKAVTIT-----------------NSRHILAGN 218
            :|..  |||   .|.:...||.| .:.||||.||.:.::                 |.:|:||..
Worm   203 KEKI--AKLPDFSKWSSHKLACLQFTLGTTGAPKLIALSHYQMLNGARAVAAAFGINDKHVLACA 265

  Fly   219 YHLTTADVQYSHNTLDWITGLLTTITSGVFST-TRIIADNAFD-PAFALRIIEEYKVTWTIQPPS 281
            ..:             :...:...|....|.| .|||..:|.. |......:.:|:.|..:...:
Worm   266 LPI-------------FRIAIFNLICLSPFLTECRIIFPDATPLPKNLFSSVSKYRCTTLLSNGA 317

  Fly   282 SMALMINCPDFETCDMSSLRCYMFGGSRAALEVQKGIRSRLSH-DCLQFVYGFTELGAMATINCH 345
            ::.|::.....:...:|:|...:..|.|.:.||.|.|:.:..: ..:...|..||.|::..:...
Worm   318 ALRLLLKISQTQRVKLSALENILLIGDRVSKEVLKLIKVQAENVKIIAVGYLLTETGSIPLMGDQ 382

  Fly   346 FDEKTGSVGQLVNGLKMKIINDDGESLGPDEIGEV--CIMNNQHWSGYYGNEVETRNMRDSLGWY 408
            ..:.|.:||:.:.|.:..:|..|| |....|.|::  .::...:.|.:.|...:|:....   |.
Worm   383 NSDFTRNVGKAIAGYEAHLIPLDG-SENQVETGKLGKLLIRVYYGSTFMGYAPDTKGKEK---WV 443

  Fly   409 HSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPN-DIESVISEMPQVAEVCVFGIWSNIFGDEAA 472
            .:||:|.||.:|.:.::..:.:::..:|.....: ::|.::::...:..|.|.   |...|....
Worm   444 DTGDIGRMDENGAIEVVASEDDLIYDKNNCLVEHWNLERLLNQNDLIKGVQVV---SRGRGQPVT 505

  Fly   473 AAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAVIVDDLQR 515
            |..|.: .::..|..:.|.::|...|.:.........|||..|
Worm   506 AVCVAR-STQFHAAKLKDELKSMCRSHHFVAPDVFAFVDDFPR 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	115/545 (21%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	108/521 (21%)
acs-16	NP_490859.1	CaiC	35..565	CDD:223395	113/540 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810