DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6300 and ACSM2A

DIOPT Version :9

Sequence 1:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001295101.1	Gene:	ACSM2A / 123876	HGNCID:	32017	Length:	577	Species:	Homo sapiens

Alignment Length:	513	Identity:	119/513 - (23%)
Similarity:	203/513 - (39%)	Gaps:	68/513 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ELLANAMRLASYMR-SLGLLQSDIVGIIGRNTTHMLAVAYACFFNGIAFHSLNITY-DRDTIEKI 123
            ||..|:.:.|:.:. :.||.:.|.|.::.........|...|...|:.|....|.. ..|.:.::
Human    85 ELSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRL 149

  Fly   124 YKVTRPSIIFCDG--DEFEKVRSATAELDVKIVTMRNHPLDSIKIDEVVATPIEENFQPAKLEKG 186
            ......:|:..|.  .|.:.|.|....|.:|::.........:...:::.   |.:.....:|.|
Human   150 QMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLN---EASTTHHCVETG 211

  Fly   187 NDQTLAILCSSGTTGTPKAVTITNSRHIL-----AGNYHLTTADVQYSHNTLDWITGLLTTITS- 245
            :.:..||..:|||:|.||....:.|...|     ||...|..:|:.::.:...||..:|.::..
Human   212 SQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEP 276

  Fly   246 ---GVFSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDMSSLR------ 301
               |..:...::.  .|||...|:.:..|.:...:..|....:::.      .|:||.:
Human   277 WALGACTFVHLLP--KFDPLVILKTLSSYPIKSMMGAPIVYRMLLQ------QDLSSYKFPHLQN 333

  Fly   302 CYMFGGS--RAALE---VQKGIRSRLSHDCLQFVYGFTELGAMATINCHFDEKTGSVGQLVNGLK 361
            |...|.|  ...||   .|.|:..|.|       ||.||.|....::.....|.|.:|...:...
Human   334 CVTVGESLLPETLENWRAQTGLDIRES-------YGQTETGLTCMVSKTMKIKPGYMGTAASCYD 391

  Fly   362 MKIINDDGESLGPDEIGEVCIMNNQ-----HWSGYYGNEVET-RNMRDSLGWYHSGDLGYMDRDG 420
            ::||:|.|..|.|...|::.|....     .:|||..|..:| .|:|... |. .||.|..|.||
Human   392 VQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDF-WL-LGDRGIKDEDG 454

  Fly   421 FLYIMDRKKEMLKYQNIMYYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKLGSELEA 485
            :...|.|..:::........|:::|:.:.|.|.|.|..|......:.|:...|.||  |.|:..:
Human   455 YFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVV--LASQFLS 517

  Fly   486 QD-------VVDYVRSRTDSKYKQ-------LNGGAVIVDDLQRS-ANGKTNRMANKA 528
            .|       :..:|:|.| :.||.       ||....:...:||: ...|..:|:.||
Human   518 HDPEQLTKELQQHVKSVT-APYKYPRKIEFVLNLPKTVTGKIQRAKLRDKEWKMSGKA 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	116/506 (23%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	116/505 (23%)
ACSM2A	NP_001295101.1	AFD_class_I	40..568	CDD:388389	116/505 (23%)
		Coenzyme A binding. /evidence=ECO:0000269\|PubMed:19345228	469..471		0/1 (0%)
		Coenzyme A binding. /evidence=ECO:0000269\|PubMed:19345228	540..542		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920