Protein Alignment GluClalpha and CHRNA6

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_004189.1
• Gene: CHRNA6 / 8973
• HGNCID: 15963
• Length: 494
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 65/285 - (22%)
• Similarity: 119/285 - (41%)
• Gaps: 21/285 - (7%)

  Fly    46 YDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYL 110
            |:..|||  :.....|..|...:.:..::.:|:|.......|..|..|.|.:|::|.::......
Human    45 YNQFIRP--VENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIET 107

  Fly   111 TLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQ 175
            ....|:::|.||:...|...|.|.  :.......:..||.:.::.......:|||::..:|.|.|
Human   108 LRVPADKIWKPDIVLYNNAVGDFQ--VEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQ 170

  Fly   176 ICSLRMASYGWTTN----DLVFLWKEGDPVQVVKNLHLPRFTLEKFLTDYCNSKTNTGE--YSCL 234
            .|||:..|  ||.:    ||:.:..:.|.....:|..........:..|.   |.|..|  |:.:
Human   171 NCSLKFGS--WTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDI---KYNCCEEIYTDI 230

  Fly   235 KVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWL--DQGAVPARVSLGVTTLLTMATQTSGINAS 297
            ......:|...:|.|.:.|||..:..::.:.|:|  |.|   .:|:|.::.||::......|..:
Human   231 TYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCG---EKVTLCISVLLSLTVFLLVITET 292

  Fly   298 LPPVSYTKAIDVWTGVCLTFVFGAL 322
            :|..|....: |...:..|.:|..|
Human   293 IPSTSLVVPL-VGEYLLFTMIFVTL 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	65/285 (23%)
CHRNA6	NP_004189.1	LIC	34..484	CDD:455710	65/285 (23%)
		LGIC_ECD	34..240	CDD:475126	45/203 (22%)