DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and glra4a

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_005169655.1	Gene:	glra4a / 83413	ZFINID:	ZDB-GENE-010410-3	Length:	457	Species:	Danio rerio

Alignment Length:	484	Identity:	199/484 - (41%)
Similarity:	267/484 - (55%)	Gaps:	70/484 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILYFAS--------LCSASLANNAKINFREKEKKV-----LDQILG-AGKYDARIRPSGINGTDG 60
            |||..|        :...|.....|.:.|..:|.:     ||:::| ...|||||||:    ..|
Zfish     8 ILYVLSFFFFQGGFIRLGSCKEEIKSSSRPAQKPMSPSDFLDKLMGRTSGYDARIRPN----FKG 68

  Fly    61 PAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLF 124
            |.| |..|||:.|...|.:.||:|.:.:..|:||.|.||.:.:.......|..:..:.:|.||||
Zfish    69 PPVNVTCNIFINSFGSITETTMDYRLNVFLRQQWNDPRLAYSEYPDASLDLDPSMLDSIWKPDLF 133

  Fly   125 FSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTN 189
            |:|||..:||.:...|..:|||.||:||||||::|.|:|||:||.:|:|.|.|::::.|:|:|.|
Zfish   134 FANEKGANFHEVTTDNKLLRIFQNGNVLYSIRLTLILSCPMDLKNFPMDIQTCTMQLESFGYTMN 198

  Fly   190 DLVFLWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIY 252
            ||:|.|...:||||..:|.||:|.|  ||.| .||....|||:::|::|....:|:..|||||:|
Zfish   199 DLIFEWLSDNPVQVADDLTLPQFVLKEEKDL-GYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMY 262

  Fly   253 IPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTF 317
            ||..::||:||||||::..|.||||.||:||:|||.||:||..||||.|||.||||:|..|||.|
Zfish   263 IPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLF 327

  Fly   318 VFGALLEFALVNYASRSGSNKANMHKENM---KKKRRDLEQASLDAAS-----------DLLDTD 368
            ||.||||:|.||:.||       .|||.:   ||:||...:..|...|           ..|.|.
Zfish   328 VFAALLEYAAVNFVSR-------QHKEFIRLRKKQRRQRIEEELVRESRGFYFRGYGLGHCLQTK 385

  Fly   369 SNATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRID 433
            .......:|.||     ..|.|:...|..|:.||                      |..|:||||
Zfish   386 DGTAVEGSSVFA-----PPPPVQVLYDGEAVRKR----------------------FVDRAKRID 423

  Fly   434 VISRITFPLVFALFNLVYWSTYLFREEED 462
            .|||..|||.|.:||:.||.||.....||
Zfish   424 TISRAVFPLSFLIFNVFYWITYKVLRHED 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	195/475 (41%)
glra4a	XP_005169655.1	LIC	27..445	CDD:273305	190/456 (42%)
		Neur_chan_LBD	48..254	CDD:280998	91/210 (43%)
		Neur_chan_memb	261..442	CDD:280999	89/214 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3541
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	345	1.000	Inparanoid score	I2297
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	1	1.000	-	-		FOG0000759
OrthoInspector	1	1.000	-	-		otm24998
orthoMCL	1	0.900	-	-		OOG6_101785
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980