Protein Alignment GluClalpha and Gabrg3

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_077346.3
• Gene: Gabrg3 / 79211
• RGDID: 621735
• Length: 467
• Species: Rattus norvegicus
• Alignment Length: 464
• Identity: 146/464 - (31%)
• Similarity: 227/464 - (48%)
• Gaps: 89/464 - (19%)

  Fly    36 VLDQILGAGKYDARIRPS-GINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99
            :|:::|  .:||.::||. ||.    |.|:.|:|:|.||..:..:.|||.:.:.|.:.|||.||:
  Rat    50 ILNKLL--REYDKKLRPDIGIK----PTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLR 108

  Fly   100 FDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLA 162
            |:   ..:|.|||..  ...:|:||..|.|.|....|.|..||..:||:.:|.:||::|:::...
  Rat   109 FN---STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170

  Fly   163 CPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVV--KNLHLPRFTLEKFLTDYCNSK 225
            |.:.|..:|:|...|.|..:|||:...::::.|:: :.|:..  |:..|.:|       |:...:
  Rat   171 CQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRWRK-NSVEAADQKSWRLYQF-------DFMGLR 227

  Fly   226 -------TNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTT 283
                   |:.|:|..:.:.....|...|:.||.||||.:.|::||||||:.:.|.|||.:||:||
  Rat   228 NTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITT 292

  Fly   284 LLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKK 348
            :|||.|.::....|||.|||..|:|::..||..|||.||:|:|.:||.|       :..|..::|
  Rat   293 VLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS-------SCRKPTIRK 350

  Fly   349 KRRDL----------EQASLDAASD--LLD---------TDSNATFAMASQFARGGGQQKPLVRH 392
            |:..|          ::.||.|.|:  |||         |.:|:.:....:
  Rat   351 KKTSLLHPDSTRWIPDRISLQAPSNYSLLDMRPPPPVMITLNNSMYWQEFE-------------- 401

  Fly   393 PGDPLALE--KRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRI-------DVISRITFPLVFALFN 448
              |....|  ....|:...       ||.........|..||       |..||:.||..|.|||
  Rat   402 --DTCVYECLDGKDCQSFF-------CCYEECKSGSWRRGRIHIDVSELDSYSRVFFPTSFLLFN 457

  Fly   449 LVYWSTYLF 457
            ||||..||:
  Rat   458 LVYWVGYLY 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	144/460 (31%)
Gabrg3	NP_077346.3	LIC	50..464	CDD:455710	144/460 (31%)
		LGIC_ECD_GABAAR_G	71..252	CDD:349801	54/191 (28%)
		Cys-loop	171..185	CDD:349801	4/13 (31%)