DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluClalpha and Gabre

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_075579.1	Gene:	Gabre / 65191	RGDID:	68320	Length:	989	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	128/454 - (28%)
Similarity:	211/454 - (46%)	Gaps:	57/454 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KEKKVLDQILGAGKYDARIRPS-GINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTD 95
            :..::|:.||  ..||.::||| |    :.|.||.|.:||.|:..|..:.||||:.:.|.:.|.|
  Rat   554 RASQILNTIL--SNYDHKLRPSIG----EKPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYD 612

  Fly    96 ERLKFDD------IQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYS 154
            |||:::|      :.|.:       .:::|:||.||.|.|....::|.:||....|..:|.|||:
  Rat   613 ERLRYNDTFETLILHGNV-------VSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKVLYT 670

  Fly   155 IRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTLEKFLT 219
            :|:::...|.:::..:|:|...|.|..:|:.:..:::::.|:........||    .:.|.:|..
  Rat   671 VRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYDEHEMIYKWENFKLKIDAKN----TWKLLEFDF 731

  Fly   220 DYCNSKTN-----TGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSL 279
            ...|:||.     .|::..:.......|.|.:.:.|.|||..:..::||||||:...|..||.|:
  Rat   732 TGVNNKTEIISTPVGDFMVMTFFFNVSRRFGFIVFQNYIPSSVTTMLSWVSFWIKIEAAAARASV 796

  Fly   280 GVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYAS-----RSGSNKA 339
            ||:::|||||..:....:.|.|||..|:|.:..:|....|..||||.::|:.:     |..|.|.
  Rat   797 GVSSVLTMATLGTFSRKNFPRVSYLTALDFYIAICFVLCFCTLLEFTVLNFLTYNNIERQASPKF 861

  Fly   340 NMHKENMKKKRRDLEQASLDAASDLLDTDSNATFAMA----SQFARGGGQQKPLVRHPGDP---- 396
            .....|.:...|...:|...|.:..........|...    .:.|..|.|..|..|.|..|
  Rat   862 YQFPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSPRSRRPQCPWRRC 926

  Fly   397 ------LALEKRLQCEVHMQAPKRPNC-CKTW-LSKFPTRSKRIDVISRITFPLVFALFNLVYW 452
                  ..:.::..|.|       |.| ..:| ..:......|:|..||:.||:.|..||:|||
  Rat   927 GRSYVCFRVLRKYFCMV-------PGCEGNSWQRGRICIHVYRLDNYSRVLFPITFFFFNVVYW 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	128/454 (28%)
Gabre	NP_075579.1	Neur_chan_LBD	555..760	CDD:280998	60/221 (27%)
		LIC	557..983	CDD:273305	126/449 (28%)
		Neur_chan_memb	769..983	CDD:280999	63/220 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910