Protein Alignment GluClalpha and Gabrq

DIOPT Version :9

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_065234.1
• Gene: Gabrq / 57249
• MGIID: 1888498
• Length: 638
• Species: Mus musculus
• Alignment Length: 606
• Identity: 152/606 - (25%)
• Similarity: 250/606 - (41%)
• Gaps: 191/606 - (31%)

  Fly    22 ANNAKINFREKEKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQ 86
            ||.|.:      :|:||::|..  ||.|:||   |....|..|.|:|:|.||.:|.::.|:|::.
Mouse    54 ANEAVV------QKILDRVLST--YDVRLRP---NFGGAPVPVSVSIYVSSIEQISEINMDYTIT 107

  Fly    87 LTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSV 151
            :...:.|.|.||.:.:....|. |......::|:||.:|.|.|:...|::.:.|...::.|:|:|
Mouse   108 MFLHQTWKDTRLAYYETNLNLT-LDYRMHEKLWVPDCYFVNSKDAFVHDVTVENRVFQLHPDGTV 171

  Fly   152 LYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTLEK 216
            .|.||::.|.||.::|:.:|:|:|.|.|.:.|||:|..|:|..|::.:.:.:...||:|::|
Mouse   172 RYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWEDDNAIHITDGLHIPQYT--- 233

  Fly   217 FLTDYCNSKT---NTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVS 278
            :|.....||.   .||.|..|.|....:||...||:|:|.|..:..|:||:|||::..:..|||:
Mouse   234 YLGRTITSKEVYFYTGSYMRLIVKFQVQREVRSYLVQVYWPTVLTTILSWISFWMNYDSSAARVT 298

  Fly   279 LGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHK 343
            :|:|::|.:.|..|.:...||.:|..||||::..|||.|||.:|||:..:||...|...:.| |:
Mouse   299 IGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVCLFFVFLSLLEYVYINYLFFSQVPRRN-HR 362

  Fly   344 ENMKKKR---------------RD-------------------------------------LEQA 356
            ...|.:|               :|                                     .|||
Mouse   363 RCRKPRRVVARYRYQEVVVANVQDGLINVEDRVEDRAGPLPDSPMQAHLASQESLGSLVFTSEQA 427

  Fly   357 SL---------------------DAASDLLDT--------------------------------- 367
            .|                     ::.|||..|
Mouse   428 QLATSESLSLLSSASSQTQLATGESLSDLPSTSEQTVPECTIHFHGFLTNDSIIPIKIHSRSDAC 492

  Fly   368 -DSNATFAMASQFARGGGQQKPLVRHPG-------------------------DPLAL------- 399
             |.::..:::|:.:.|.|..     |.|                         |.:::
Mouse   493 DDEDSEESLSSEESHGHGSS-----HTGRLKLQISQRCVQEASWDLDKIEILQDDISITSSWLGL 552

  Fly   400 ----------------EKRLQC--EVHMQAPKRPNCCKTWLSKF----------PTRSKRIDVIS 436
                            |:.:.|  |....:....||..:....|          |.|..::|..|
Mouse   553 DEQCKGDADSIWSLTDEELMACDQEKDSSSESEENCSPSPGCSFNEGFSFQLFKPNRVPKVDRWS 617

  Fly   437 RITFPLVFALFNLVYWSTYLF 457
            |..|||.|.|||:|||..:::
Mouse   618 RFLFPLSFGLFNVVYWLYHVY 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	152/602 (25%)
Gabrq	NP_065234.1	LGIC_ECD_GABAAR_theta	82..263	CDD:349804	58/184 (32%)
		Cys-loop	183..197	CDD:349804	5/13 (38%)
		LGIC_TM_GABAAR_theta	266..365	CDD:349858	40/99 (40%)
		TM1 helix	266..289	CDD:349858	11/22 (50%)
		TM2 helix	293..317	CDD:349858	8/23 (35%)
		TM3 helix	325..351	CDD:349858	14/25 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..515		5/28 (18%)
		LGIC_TM	<604..636	CDD:365787	15/31 (48%)
		TM4 helix	612..633	CDD:349850	11/20 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910