DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluClalpha and Gabrq

DIOPT Version :10

Sequence 1:NP_001287408.1 Gene:GluClalpha / 42350 FlyBaseID:FBgn0024963 Length:463 Species:Drosophila melanogaster
Sequence 2:NP_065234.1 Gene:Gabrq / 57249 MGIID:1888498 Length:638 Species:Mus musculus


Alignment Length:606 Identity:152/606 - (25%)
Similarity:250/606 - (41%) Gaps:191/606 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ANNAKINFREKEKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQ 86
            ||.|.:      :|:||::|..  ||.|:||   |....|..|.|:|:|.||.:|.::.|:|::.
Mouse    54 ANEAVV------QKILDRVLST--YDVRLRP---NFGGAPVPVSVSIYVSSIEQISEINMDYTIT 107

  Fly    87 LTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSV 151
            :...:.|.|.||.:.:....|. |......::|:||.:|.|.|:...|::.:.|...::.|:|:|
Mouse   108 MFLHQTWKDTRLAYYETNLNLT-LDYRMHEKLWVPDCYFVNSKDAFVHDVTVENRVFQLHPDGTV 171

  Fly   152 LYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTLEK 216
            .|.||::.|.||.::|:.:|:|:|.|.|.:.|||:|..|:|..|::.:.:.:...||:|::|   
Mouse   172 RYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWEDDNAIHITDGLHIPQYT--- 233

  Fly   217 FLTDYCNSKT---NTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVS 278
            :|.....||.   .||.|..|.|....:||...||:|:|.|..:..|:||:|||::..:..|||:
Mouse   234 YLGRTITSKEVYFYTGSYMRLIVKFQVQREVRSYLVQVYWPTVLTTILSWISFWMNYDSSAARVT 298

  Fly   279 LGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHK 343
            :|:|::|.:.|..|.:...||.:|..||||::..|||.|||.:|||:..:||...|...:.| |:
Mouse   299 IGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVCLFFVFLSLLEYVYINYLFFSQVPRRN-HR 362

  Fly   344 ENMKKKR---------------RD-------------------------------------LEQA 356
            ...|.:|               :|                                     .|||
Mouse   363 RCRKPRRVVARYRYQEVVVANVQDGLINVEDRVEDRAGPLPDSPMQAHLASQESLGSLVFTSEQA 427

  Fly   357 SL---------------------DAASDLLDT--------------------------------- 367
            .|                     ::.|||..|                                 
Mouse   428 QLATSESLSLLSSASSQTQLATGESLSDLPSTSEQTVPECTIHFHGFLTNDSIIPIKIHSRSDAC 492

  Fly   368 -DSNATFAMASQFARGGGQQKPLVRHPG-------------------------DPLAL------- 399
             |.::..:::|:.:.|.|..     |.|                         |.:::       
Mouse   493 DDEDSEESLSSEESHGHGSS-----HTGRLKLQISQRCVQEASWDLDKIEILQDDISITSSWLGL 552

  Fly   400 ----------------EKRLQC--EVHMQAPKRPNCCKTWLSKF----------PTRSKRIDVIS 436
                            |:.:.|  |....:....||..:....|          |.|..::|..|
Mouse   553 DEQCKGDADSIWSLTDEELMACDQEKDSSSESEENCSPSPGCSFNEGFSFQLFKPNRVPKVDRWS 617

  Fly   437 RITFPLVFALFNLVYWSTYLF 457
            |..|||.|.|||:|||..:::
Mouse   618 RFLFPLSFGLFNVVYWLYHVY 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluClalphaNP_001287408.1 LIC 3..455 CDD:273305 152/602 (25%)
GabrqNP_065234.1 LGIC_ECD_GABAAR_theta 82..263 CDD:349804 58/184 (32%)
Cys-loop 183..197 CDD:349804 5/13 (38%)
LGIC_TM_GABAAR_theta 266..365 CDD:349858 40/99 (40%)
TM1 helix 266..289 CDD:349858 11/22 (50%)
TM2 helix 293..317 CDD:349858 8/23 (35%)
TM3 helix 325..351 CDD:349858 14/25 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..515 5/28 (18%)
LGIC_TM <604..636 CDD:476813 15/31 (48%)
TM4 helix 612..633 CDD:349858 11/20 (55%)

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