DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and gabrb3

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_005166136.1	Gene:	gabrb3 / 566922	ZFINID:	ZDB-GENE-101102-2	Length:	532	Species:	Danio rerio

Alignment Length:	527	Identity:	169/527 - (32%)
Similarity:	261/527 - (49%)	Gaps:	96/527 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FWAIL----YFASLCSASLANNAKINFREK-----------------EKKVLDQILGAGKYDARI 50
            ||::.    :.|...:|.|.|...::..:|                 .|:.:|::|..  ||.|:
Zfish    24 FWSVYGELPFIAENNAAMLVNWNAVDGNKKLFAIYDTSANEPGNMSFVKETVDKLLKG--YDIRL 86

  Fly    51 RPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEA 115
            ||. ..|  .|..|.::|.|.||..:.:|.|:|::.:.|::.|.|:||.:..|.     |.||..
Zfish    87 RPD-FGG--APVAVGMSIDVASIDMVSEVNMDYTLTMYFQQYWRDKRLAYTGIP-----LNLTLD 143

  Fly   116 NRV----WMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQI 176
            |||    |:||.:|.|:|:...|.:.:.|..||:.|:|:|||.:||:.|.||.|:|:.||||.|.
Zfish   144 NRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQN 208

  Fly   177 CSLRMASYGWTTNDLVFLWKEGD-PVQVVKNLHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLF 240
            |:|.:.|||:||:|:.|.||.|: .|..|..:.||:|::..:.....|...:||.|..|.:....
Zfish   209 CTLEIESYGYTTDDIEFYWKGGETAVTGVSRIELPQFSIVDYKLVSRNVVFSTGAYPRLSLSFKL 273

  Fly   241 KREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTK 305
            ||...|:::|.|:|..::.|:||||||::..|..|||:||:||:|||.|..:.:..:||.:.|.|
Zfish   274 KRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVK 338

  Fly   306 AIDVWTGVCLTFVFGALLEFALVNY---------------ASRSGSNKANMH------KENMKKK 349
            |||::...|..|||.||||:|.|||               .:...:|..|.:      :|....|
Zfish   339 AIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQMQKKLAEKAEKANNDRNKYDGNKSVQEGGNCK 403

  Fly   350 RRDLEQAS----------LDAASDLLDTD----------------SNATFAMASQFARGGGQ--Q 386
            ...::|::          :|:..::|.|.                |.|..:.:..|...|.|  :
Zfish   404 PSSVKQSNQVQGHRHSRGVDSQGNILLTTLEIHNEVAGNEITTSVSEARNSTSMVFDNSGIQYRK 468

  Fly   387 KPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFP--TRSKRIDVISRITFPLVFALFNL 449
            :...||..|..|..|:.:..      :|.:..|.   |.|  |....||..|||.||.||:||||
Zfish   469 QSTARHSMDRNAQSKKPRLR------RRSSQLKI---KIPDLTDVNAIDRWSRIIFPAVFSLFNL 524

  Fly   450 VYWSTYL 456
            :||..|:
Zfish   525 IYWLYYV 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	168/524 (32%)
gabrb3	XP_005166136.1	LIC	61..530	CDD:273305	161/487 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910