DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluClalpha and ort

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_524406.1	Gene:	ort / 45910	FlyBaseID:	FBgn0003011	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	154/493 - (31%)
Similarity:	232/493 - (47%)	Gaps:	74/493 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LCSASLANNAKINFREKEKKVLDQIL--GAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDD 78
            :|:..:.:.||..|  ::...:..||  ...:|| ::||....|.  |.:|..::.|..:..||:
  Fly    10 ICTICMKHYAKGEF--QQSLAITDILPEDIKRYD-KMRPPKKEGQ--PTIVYFHVTVMGLDSIDE 69

  Fly    79 VTMEYSVQLTFREQWTDERLKF-DDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVY 142
            .:|.|...:.|.:.|.|.||:. :::....:.|.:.....:|.||.||.|.|...|..:.:||.|
  Fly    70 NSMTYVADVFFAQTWKDHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHY 134

  Fly   143 IRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNL 207
            :.::.:.::||.::::|.|:|.||..:||.|.|.|.|:|.|...||:||:|.|....|:.|.:|:
  Fly   135 MWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENI 199

  Fly   208 HLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGA 272
            .||:..|.:..|..|....:||.::||:|....||...||:...|||.||:||:||||||:...|
  Fly   200 ELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEA 264

  Fly   273 VPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNY------- 330
            .||||:||||:|||::||.:...:|||||||.||:|.:..||..|||.||:|:.|:|.
  Fly   265 APARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPI 329

  Fly   331 ----------------------ASRSGSNK------------ANMHKENMKK------KRRDLEQ 355
                                  |...|||.            |:...|.::|      |.|.:..
  Fly   330 PKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVT 394

  Fly   356 ASLDAASDLLDTDSNATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKT 420
            .:.......||.|........|:..     ..|.:..|..|           ...|...|...|.
  Fly   395 TTRRVVRPPLDADGPWIPRQESRII-----LTPTIAPPPPP-----------PQPAAPEPELPKP 443

  Fly   421 WLSKFPTRSKR---IDVISRITFPLVFALFNLVYWSTY 455
            .|:....|.||   ||..||:.||.:||..|.:||..:
  Fly   444 KLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVF 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	154/491 (31%)
ort	NP_524406.1	LIC	31..481	CDD:273305	150/468 (32%)
		Neur_chan_LBD	38..235	CDD:280998	64/199 (32%)
		Neur_chan_memb	243..>334	CDD:280999	47/90 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020