Protein Alignment GluClalpha and nAChRbeta2

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 360
• Identity: 83/360 - (23%)
• Similarity: 157/360 - (43%)
• Gaps: 82/360 - (22%)

  Fly     6 YFWAILYFASLCSASLANN-AKINFREK--EKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVN 67
            :.|::|....|  ..|||: |.|:|...  .|::.|.:|  ..|:..|||. :|.|:     .:.
  Fly     2 WHWSLLCVFLL--VPLANSTAPISFEANPDTKRLYDDLL--SNYNRLIRPV-VNNTE-----TLT 56

  Fly    68 IFV-RSISKIDDVTMEYSVQLT---FREQWTDERLKFD-DIQGRLKYLTLTEANRVWMPDLFFSN 127
            ::: ..:|::.:|.::..|..|   .:::|.|.:|::| :..|.::.| ...:..:|:||:...|
  Fly    57 VWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQL-YVPSEHIWVPDIVLYN 120

  Fly   128 EKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTN--- 189
            ..:|::...:|....::.  .|.|.:........:|.||::.:|.|.|||.::..|  ||.|
  Fly   121 NWDGNYEVTLMTKATLKY--TGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGS--WTYNGAQ 181

  Fly   190 -------------------DLV--FLWKEGDPVQV--VKNLHLPRFTLEKFLTDYCNSKTNTGEY 231
                               ||.  :|..|.|.::|  .||......|||.|
  Fly   182 VDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPF-------------- 232

  Fly   232 SCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWL--DQGAVPARVSLGVTTLLTMATQTSGI 294
            |.:...|..:|:..:|.:.:.:||..|..::.:.|:|  |.|   .:|:|.::.|:::......:
  Fly   233 SDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSG---EKVTLCISILVSLTVFFLLL 294

  Fly   295 NASLPPVS-----------YTK---AIDVWTGVCL 315
            ...:||.|           :|.   ::.|||.||:
  Fly   295 AEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCV 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	83/360 (23%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	81/353 (23%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	54/244 (22%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)