Protein Alignment GluClalpha and ZACN

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_851321.2
• Gene: ZACN / 353174
• HGNCID: 29504
• Length: 412
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 63/301 - (20%)
• Similarity: 112/301 - (37%)
• Gaps: 39/301 - (12%)

  Fly    56 NGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWM 120
            |....|.:|.|.:||.::..:|.:....|..|..|..|.|.||.::........:||...: :|.
Human    54 NNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPWES-LWT 117

  Fly   121 PDLFFSNEKEGHFHNIIMPNVYI---------RIFPNGSVLYSIRISLTLACPMNLKLYPLDRQI 176
            |.|            .|:..:::         |:..:|.|..::.::....|...|..:|.|...
Human   118 PRL------------TILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSN 170

  Fly   177 CSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFK 241
            |||...:...|..:|.|.....:.:..||.        |..:.|............|.:|.|..|
Human   171 CSLSFYALSNTAMELEFQAHVVNEIVSVKR--------EYVVYDLKTQVPPQQLVPCFQVTLRLK 227

  Fly   242 REFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKA 306
            ......:|.:.:|...|::.......|...|: .|:...||.||:.....|.:..:||..|....
Human   228 NTALKSIIALLVPAEALLLADVCGGLLPLRAI-ERIGYKVTLLLSYLVLHSSLVQALPSSSSCNP 291

  Fly   307 IDV-WTGVCLTFVFGALLEFALV-------NYASRSGSNKA 339
            :.: :..:.|..:|.:.:|..|:       |..::||.:.|
Human   292 LLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPA 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	63/301 (21%)
ZACN	NP_851321.2	LGIC_ECD_ZAC	60..229	CDD:349795	39/189 (21%)
		Cys-loop	157..171	CDD:349795	4/13 (31%)
		LGIC_TM	231..407	CDD:476813	22/103 (21%)
		TM1 helix	235..255	CDD:349850	3/19 (16%)
		TM2 helix	263..284	CDD:349850	5/20 (25%)
		TM3 helix	295..317	CDD:349850	4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	328..360		2/5 (40%)
		TM4 helix	365..386	CDD:349850