Protein Alignment GluClalpha and nAChRalpha7

DIOPT Version :9

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_001162795.1
• Gene: nAChRalpha7 / 32928
• FlyBaseID: FBgn0086778
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 115/562 - (20%)
• Similarity: 204/562 - (36%)
• Gaps: 163/562 - (29%)

  Fly     6 YFWAILYFASLCSASLANNAKINFREKEKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFV 70
            |...:|.....|:|.          ..||::|..:|  ..|::..||. :|.:| |..:...:.:
  Fly    44 YGLGLLIMIPACAAG----------PHEKRLLHALL--DNYNSLERPV-VNESD-PLQLSFGLTL 94

  Fly    71 RSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQ-GRLKYLTLTEANRVWMPDLFFSNEKEGHFH 134
            ..|..:|:........:..:.:|.|..|:::..: |.::.|.: ..:|:|.||:...|..:..|.
  Fly    95 MQIIDVDEKNQLLITNIWLKLEWNDMNLRWNSSEFGGVRDLRI-PPHRLWKPDVLMYNSADEGFD 158

  Fly   135 NIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTN----DLVFLW 195
            .....||.:|  .|||.||.........|.:::..:|.|.|.|.::..|  ||.:    ||. |.
  Fly   159 GTYATNVVVR--NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGS--WTYDGFQLDLQ-LQ 218

  Fly   196 KE--GDPVQVVKN-----LHLPRFTLEKFLTDYCNSKTNTGEYSCLK---VDLLF----KREFSY 246
            .|  ||....:.|     |.:|             .|.|...|:|..   :|:.|    :|:..|
  Fly   219 DEAGGDISSFITNGEWDLLGVP-------------GKRNEIYYNCCPEPYIDITFAILIRRKTLY 270

  Fly   247 YLIQIYIPCCMLVIVSWVSFWL--DQGAVPARVSLGVTTLLTMATQTSGINASLPPVS------- 302
            |...:.:||.::..::.:.|.|  |.|   .::|||||.||::....:.:..::|..|
  Fly   271 YFFNLIVPCVLIASMALLGFTLPPDSG---EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLG 332

  Fly   303 ----------------------Y------TKAIDVWTGVCLTFVFGALLEF---ALVNY------ 330
                                  |      |..:..|..|...:....:|..   ..|.|
  Fly   333 TYFNCIMFMVASSVVSTILILNYHHRNPDTHEMSEWIRVIFLYWLPCILRMQRPGQVGYECPPPP 397

  Fly   331 --ASRSGSNKANMHKENMKKKRRDLEQASLDAASDLLDTD---------SNATFAMASQFAR--- 381
              :|.|.|.:.....:|::.|    |::|....:::||.|         ::||......:.|
  Fly   398 SSSSSSASGEKKQQIQNVELK----ERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMY 458

  Fly   382 ---GGGQQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKT---------------WLSKFPTR 428
               ..|...|:  .|..|: ::.||...:       .:.|.|               |:::   :
  Fly   459 RQGDDGSVGPV--GPAGPV-VDGRLHEAI-------SHTCLTSSAEYELALILKELRWITE---Q 510

  Fly   429 SKRIDVISRITFP-------------LVFALFNLVYWSTYLF 457
            .|:.|..|.||..             ::|.||.::.....||
  Fly   511 LKKEDETSDITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLF 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	113/558 (20%)
nAChRalpha7	NP_001162795.1	LIC	59..548	CDD:273305	109/531 (21%)
		Neur_chan_LBD	61..268	CDD:280998	55/229 (24%)
		Neur_chan_memb	275..552	CDD:280999	52/296 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030