DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and Gabra1

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_899155.1	Gene:	Gabra1 / 29705	RGDID:	61855	Length:	455	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	166/481 - (34%)
Similarity:	250/481 - (51%)	Gaps:	60/481 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GSGHYFWA-ILYFASLCSASLANNAKINFREKE---KKVLDQILGAGKYDARIRPS-GINGTDGP 61
            |...|.|| .|..::|...|....::...::..   .::||::|..  ||.|:||. |...|:
  Rat     6 GLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDG--YDNRLRPGLGERVTE-- 66

  Fly    62 AVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTE--ANRVWMPDLF 124
              |:.:|||.|...:.|..|||::.:.||:.|.||||||   :|.:..|.|..  |:::|.||.|
  Rat    67 --VKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKF---KGPMTVLRLNNLMASKIWTPDTF 126

  Fly   125 FSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTN 189
            |.|.|:...||:.|||..:||..:|::||::|:::...|||:|:.:|:|...|.|:..||.:|..
  Rat   127 FHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRA 191

  Fly   190 DLVFLWKEGDPVQVV----KNLHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQ 250
            ::|:.|.. :|.:.|    ....|.::.|.....|....:::||||..:......||:..|::||
  Rat   192 EVVYEWTR-EPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQ 255

  Fly   251 IYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCL 315
            .|:||.|.||:|.|||||::.:||||...||||:|||.|.:.....|||.|:|..|:|.:..||.
  Rat   256 TYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCY 320

  Fly   316 TFVFGALLEFALVNYASRSG---------SNKANMHKENMKKKRRDLEQASLDAASDLLDTDSN- 370
            .|||.||:|||.|||.::.|         ..|....|:.:.||.......:.....:|...|..
  Rat   321 AFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGL 385

  Fly   371 ATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRIDVI 435
            ||.|.::..               :|    |.::.|.....||     ||:.|     ..:||.:
  Rat   386 ATIAKSATI---------------EP----KEVKPETKPPEPK-----KTFNS-----VSKIDRL 421

  Fly   436 SRITFPLVFALFNLVYWSTYLFREEE 461
            |||.|||:|.:||||||:|||.||.:
  Rat   422 SRIAFPLLFGIFNLVYWATYLNREPQ 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	160/472 (34%)
Gabra1	NP_899155.1	LIC	7..441	CDD:273305	160/472 (34%)
		LGIC_ECD_GABAAR_A1	55..248	CDD:349835	68/200 (34%)
		Cys-loop	165..179	CDD:349835	6/13 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910