DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and Gabrr1

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_058987.3	Gene:	Gabrr1 / 29694	RGDID:	61900	Length:	480	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	152/446 - (34%)
Similarity:	243/446 - (54%)	Gaps:	71/446 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DQILGAGKYDARIRPSGINGTDGPAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFD 101
            :|:|....:|..:||    |..|||: |.|::.|.|:..|.:|.|::::.|..|..|.||||.|.
  Rat    77 EQLLRIDDHDFSMRP----GFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFP 137

  Fly   102 D-------IQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISL 159
            .       ..|||       ..::|:||:||.:.|....|:....||.:|:.|:|.||||:|:::
  Rat   138 STNNLSMTFDGRL-------VKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTV 195

  Fly   160 TLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEG-DPVQVVKNLHLPRFTLEKFLTDYCN 223
            |..|.|:...:|||.|.|||.:.||.:|.:||:..||:| |.::..:.:.|.:|.:::|.|   .
  Rat   196 TAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHT---T 257

  Fly   224 SK----TNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTL 284
            :|    ::||.|:.|.::...:|...::|:|.|.|..::|::||||||:|:.||||||.||:||:
  Rat   258 TKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTV 322

  Fly   285 LTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKK 349
            |||:|..:|:|||:|.|||.||:|::..|...|||.::||:|.|||          :.....:|:
  Rat   323 LTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNY----------LTTVQERKE 377

  Fly   350 RRDLEQASLDAA-----SDLLDTDSNATFAMASQFARG-----GGQ-----QKPLVRHPGDPLAL 399
            |:..|:.|....     ..:||          |.::.|     ||.     :||      |.:.:
  Rat   378 RKLREKISCTCGLPQPRGVMLD----------SSYSDGEVNDLGGYMPENGEKP------DRMMV 426

  Fly   400 EKRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTY 455
            :..|..|  ..:|:|.:...:::| ....:..||..|||.||..:.||||:|||.:
  Rat   427 QLTLASE--RGSPQRKSQRGSYVS-MRINTHAIDKYSRIIFPAAYILFNLIYWSIF 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	152/444 (34%)
Gabrr1	NP_058987.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..67
		LIC	76..479	CDD:273305	152/444 (34%)
		LGIC_ECD_GABAAR_rho	97..282	CDD:349806	65/194 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910