DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and Gabrd

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_058985.1	Gene:	Gabrd / 29689	RGDID:	61901	Length:	449	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	150/469 - (31%)
Similarity:	236/469 - (50%)	Gaps:	48/469 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WAILYFASLCSAS-------------LANNAKINFREKEKKVLDQILGAGKYDARIRPSGINGTD 59
            |.:|....||:..             :.:|.:|::...    ||.::..  |....|| ||.|.
  Rat     6 WLLLPLLLLCTQPHHGARAMNDIGDYVGSNLEISWLPN----LDGLMEG--YARNFRP-GIGGP- 62

  Fly    60 GPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLF 124
             |..|.:.:.|.||..|.:..|||::.:...:.|.|.||.::.....|. |.....:::|:||.|
  Rat    63 -PVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLG-LDSRFVDKLWLPDTF 125

  Fly   125 FSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTN 189
            ..|.|...||::.:.|..||:.|:|.:||||||:.|:||.|:|..||:|.|.|.|.:.|||:::.
  Rat   126 IVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSE 190

  Fly   190 DLVFLWKEG-DPVQVVKNLHLPRFTLE--KFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQI 251
            |:|:.|.|. :.:..:..|.|.:||:.  :|.|:..|.| :.|::..|.:....:|....|:||.
  Rat   191 DIVYYWSENQEQIHGLDRLQLAQFTITSYRFTTELMNFK-SAGQFPRLSLHFQLRRNRGVYIIQS 254

  Fly   252 YIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLT 316
            |:|..:||.:||||||:.|.|||||||||:||:|||.|......:|||..|..||:||:..:|..
  Rat   255 YMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYV 319

  Fly   317 FVFGALLEFALVNYASRSGSNKANMHKENMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFAR 381
            |||.||:|:|..::            ..:.:|||:    |.:.......:.|......:.|..|.
  Rat   320 FVFAALVEYAFAHF------------NADYRKKRK----AKVKVTKPRAEMDVRNAIVLFSLSAA 368

  Fly   382 GGGQQKPLVRH----PGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKF-PTRSKRIDVISRITFP 441
            |..|:..:.|.    ||:.:...:.::.|...:...||.......|:. |..:..||:.:|..||
  Rat   369 GVSQELAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGIRSRLKPIDADTIDIYARAVFP 433

  Fly   442 LVFALFNLVYWSTY 455
            ..||..|::||:.|
  Rat   434 AAFAAVNIIYWAAY 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	149/467 (32%)
Gabrd	NP_058985.1	LGIC_ECD	63..246	CDD:355788	62/184 (34%)
Gabrd	NP_058985.1	LGIC_TM	249..>337	CDD:365787	45/99 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910