Protein Alignment GluClalpha and GLRB

DIOPT Version :9

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_000815.1
• Gene: GLRB / 2743
• HGNCID: 4329
• Length: 497
• Species: Homo sapiens
• Alignment Length: 460
• Identity: 163/460 - (35%)
• Similarity: 259/460 - (56%)
• Gaps: 60/460 - (13%)

  Fly    36 VLDQILGAGKYDARIRPS--GINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERL 98
            :|:::|.:  ||.||||:  ||     |..|.||||:.|...|.:.||:|.|.:..|::|.|.||
Human    59 ILNRLLVS--YDPRIRPNFKGI-----PVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRL 116

  Fly    99 KF-DDIQGRLKYLTL--TEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLT 160
            |. .|.:|. ..||:  |....:|.|||||:|||..:||::...|:.:.||.:|.||.|:|:|:|
Human   117 KLPSDFRGS-DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSIT 180

  Fly   161 LACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTLEKFLTDYCNSK 225
            |:||::|.|:|:|.|.|.:::.|:|:||:||.|:|:.|||||:.| :.||:|.::|...:|.|..
Human   181 LSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEK-IALPQFDIKKEDIEYGNCT 244

  Fly   226 ---TNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTM 287
               ..||.|:|::|....:|:..:|::.:|.|..::|::||:|||::..|..|||.||:.::|::
Human   245 KYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSL 309

  Fly   288 ATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALV----NYASRSGSNKANMHKE---- 344
            |::.:.:.|.||.|||.||:|||...||.|.|.:|:|:|:|    |...|..:.||.:.|.
Human   310 ASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQAD 374

  Fly   345 ----NMKKKR------RDLEQASLD-----------AASDLLDTDSNATFAMASQFARGGGQQKP 388
                |:.||.      ..:..::|.           :.|||...|.:...::...|        .
Human   375 GKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDF--------E 431

  Fly   389 LVRHP--GDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRIDVISRITFPLVFALFNLVY 451
            |..:.  |.|:.:...|. :...:..|:|...|..:   ||.:||||:.:|..||..|..||::|
Human   432 LSNYDCYGKPIEVNNGLG-KSQAKNNKKPPPAKPVI---PTAAKRIDLYARALFPFCFLFFNVIY 492

  Fly   452 WSTYL 456
            ||.||
Human   493 WSIYL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	161/457 (35%)
GLRB	NP_000815.1	LIC	43..496	CDD:273305	161/457 (35%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	78/187 (42%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	247..253		2/5 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3644
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42124
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	8.020