Protein Alignment GluClalpha and GLRA2

DIOPT Version :9

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_001112357.1
• Gene: GLRA2 / 2742
• HGNCID: 4327
• Length: 452
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 190/434 - (43%)
• Similarity: 257/434 - (59%)
• Gaps: 41/434 - (9%)

  Fly    37 LDQILG-AGKYDARIRPSGINGTDGPAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99
            ||:::| ...|||||||:    ..||.| |..|||:.|...:.:.||:|.|.:..|:||.|.||.
Human    48 LDKLMGRTSGYDARIRPN----FKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLA 108

  Fly   100 FDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACP 164
            :.:.......|..:..:.:|.|||||:|||..:||::...|..:||..||.||||||::|||:||
Human   109 YSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCP 173

  Fly   165 MNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTN 227
            |:||.:|:|.|.|::::.|:|:|.|||:|.|....||||.:.|.||:|.|  ||.| .||....|
Human   174 MDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKEL-GYCTKHYN 237

  Fly   228 TGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTS 292
            ||:::|::|....:|:..|||||:|||..::||:||||||::..|.||||:||:||:|||.||:|
Human   238 TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSS 302

  Fly   293 GINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKKRRDLEQAS 357
            |..||||.|||.||||:|..|||.|||.||||:|.||:.||       .|||.::.:||...|..
Human   303 GSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSR-------QHKEFLRLRRRQKRQNK 360

  Fly   358 LDAASDLLDTDSNATFAMASQFARGGGQQ----KPLVRHPGDPLALEKRLQCEVHMQAPKRPNCC 418
            .:      |....:.|.. |.:..|...|    ..:...|.:||.           |.||..:..
Human   361 EE------DVTRESRFNF-SGYGMGHCLQVKDGTAVKATPANPLP-----------QPPKDGDAI 407

  Fly   419 KTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTYLFREEED 462
            |   .||..|:||||.|||..|||.|.:||:.||.||.....||
Human   408 K---KKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHED 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	186/425 (44%)
GLRA2	NP_001112357.1	LIC	46..441	CDD:273305	186/425 (44%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	236..241		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3644
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2369
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	1	1.000	-	-		FOG0000759
OrthoInspector	1	1.000	-	-		otm42124
orthoMCL	1	0.900	-	-		OOG6_101785
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.980