Protein Alignment GluClalpha and GLRA1

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: XP_047273061.1
• Gene: GLRA1 / 2741
• HGNCID: 4326
• Length: 465
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 194/467 - (41%)
• Similarity: 264/467 - (56%)
• Gaps: 43/467 - (9%)

  Fly     7 FWAILYFASLCSASLANNAKINFREKEKKV-----LDQILG-AGKYDARIRPSGINGTDGPAV-V 64
            |.:.|:..||.::..|..|    |...|.:     ||:::| ...|||||||:    ..||.| |
Human    27 FCSPLFLLSLAASKEAEAA----RSAPKPMSPSDFLDKLMGRTSGYDARIRPN----FKGPPVNV 83

  Fly    65 RVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNEK 129
            ..|||:.|...|.:.||:|.|.:..|:||.|.||.:::.......|..:..:.:|.|||||:|||
Human    84 SCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEK 148

  Fly   130 EGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFL 194
            ..|||.|...|..:||..||:|||||||:|||||||:||.:|:|.|.|.:::.|:|:|.|||:|.
Human   149 GAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFE 213

  Fly   195 WKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCM 257
            |:|...|||...|.||:|.|  ||.|. ||....|||:::|::.....:|:..|||||:|||..:
Human   214 WQEQGAVQVADGLTLPQFILKEEKDLR-YCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLL 277

  Fly   258 LVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGAL 322
            :||:||:|||::..|.||||.||:||:|||.||:||..||||.|||.||||:|..|||.|||.||
Human   278 IVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSAL 342

  Fly   323 LEFALVNYASRSGSNKANMHKE--NMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFARGGGQ 385
            ||:|.||:.||       .|||  ..::|||..::          |......|..:   |.|.|
Human   343 LEYAAVNFVSR-------QHKELLRFRRKRRHHKE----------DEAGEGRFNFS---AYGMG- 386

  Fly   386 QKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRIDVISRITFPLVFALFNLV 450
              |......|.::::...........|......:.....|..|:|:||.||||.||:.|.:||:.
Human   387 --PACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMF 449

  Fly   451 YWSTYLFREEED 462
            ||..|.....||
Human   450 YWIIYKIVRRED 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	191/458 (42%)
GLRA1	XP_047273061.1	LIC	24..454	CDD:273305	191/458 (42%)