Protein Alignment GluClalpha and GABRR1

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: XP_054211048.1
• Gene: GABRR1 / 2569
• HGNCID: 4090
• Length: 480
• Species: Homo sapiens
• Alignment Length: 444
• Identity: 152/444 - (34%)
• Similarity: 245/444 - (55%)
• Gaps: 67/444 - (15%)

  Fly    38 DQILGAGKYDARIRPSGINGTDGPAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFD 101
            :|:|....:|..:||    |..|||: |.|::.|.|:..|.:|.|::::.|..|..|.||||.|.
Human    77 EQLLRIDDHDFSMRP----GFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFP 137

  Fly   102 D-------IQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISL 159
            .       ..|||       ..::|:||:||.:.|....|:....||.:|:.|:|.||||:|:::
Human   138 STNNLSMTFDGRL-------VKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTV 195

  Fly   160 TLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEG-DPVQVVKNLHLPRFTLEKFLTDYCN 223
            |..|.|:...:|||.|.|||.:.||.:|.:||:..||:| |.::..:.:.|.:|.:::|.|   .
Human   196 TAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHT---T 257

  Fly   224 SK----TNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTL 284
            :|    ::||.|:.|.::...:|...::|:|.|.|..::|::||||||:|:.||||||.||:||:
Human   258 TKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTV 322

  Fly   285 LTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKK 349
            |||:|..:|:|||:|.|||.||:|::..|...|||.::||:|.|||.:       .:.:...:|.
Human   323 LTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLT-------TVQERKEQKL 380

  Fly   350 RRDL---------EQASLD---AASDLLDTDSNATFAMASQFARGGGQQKPLVRHPGDPLALEKR 402
            |..|         ..|.||   :..::.|.|:         :....| :||      |.:.::..
Human   381 REKLPCTSGLPPPRTAMLDGNYSDGEVNDLDN---------YMPENG-EKP------DRMMVQLT 429

  Fly   403 LQCEVHMQAPKRPNCCKTWLS-KFPTRSKRIDVISRITFPLVFALFNLVYWSTY 455
            |..|  ..:|:|.:...:::| :..|.:  ||..|||.||..:.||||:|||.:
Human   430 LASE--RSSPQRKSQRSSYVSMRIDTHA--IDKYSRIIFPAAYILFNLIYWSIF 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	152/442 (34%)
GABRR1	XP_054211048.1	LIC	76..479	CDD:455710	152/442 (34%)
		LGIC_ECD_GABAAR_rho	97..282	CDD:349806	65/194 (34%)
		Cys-loop	199..213	CDD:349806	6/13 (46%)