DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and Glra1

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_006246440.1	Gene:	Glra1 / 25674	RGDID:	2704	Length:	457	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	198/468 - (42%)
Similarity:	268/468 - (57%)	Gaps:	35/468 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YFWAILYFASLCSASLANNAKINFREKEKKV-----LDQILG-AGKYDARIRPSGINGTDGPAV- 63
            |.|..:.|.||.::..|:.|    |...|.:     ||:::| ...|||||||:    ..||.|
  Rat    10 YLWETIVFFSLAASKEADAA----RSAPKPMSPSDFLDKLMGRTSGYDARIRPN----FKGPPVN 66

  Fly    64 VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTEANRVWMPDLFFSNE 128
            |..|||:.|...|.:.||:|.|.:..|:||.|.||.:::.......|..:..:.:|.|||||:||
  Rat    67 VSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANE 131

  Fly   129 KEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVF 193
            |..|||.|...|..:||..||:|||||||:|||||||:||.:|:|.|.|.:::.|:|:|.|||:|
  Rat   132 KGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIF 196

  Fly   194 LWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCC 256
            .|:|...|||...|.||:|.|  ||.|. ||....|||:::|::.....:|:..|||||:|||..
  Rat   197 EWQEQGAVQVADGLTLPQFILKEEKDLR-YCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSL 260

  Fly   257 MLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGA 321
            ::||:||:|||::..|.||||.||:||:|||.||:||..||||.|||.||||:|..|||.|||.|
  Rat   261 LIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSA 325

  Fly   322 LLEFALVNYASRSGSNKANMHKE--NMKKKRRDLEQASLDAASDLLDTDSNATFAMASQFARGGG 384
            |||:|.||:.||       .|||  ..::|||..:...|:...|  |......|..:   |.|.|
  Rat   326 LLEYAAVNFVSR-------QHKELLRFRRKRRHHKSPMLNLFQD--DEGGEGRFNFS---AYGMG 378

  Fly   385 QQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRIDVISRITFPLVFALFNL 449
               |......|.::::..........||......:.....|..|:|:||.||||.||:.|.:||:
  Rat   379 ---PACLQAKDGISVKGANNNNTTNPAPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNM 440

  Fly   450 VYWSTYLFREEED 462
            .||..|.....||
  Rat   441 FYWIIYKIVRRED 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	195/459 (42%)
Glra1	XP_006246440.1	LIC	7..446	CDD:273305	195/459 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3542
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20083
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2275
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	1	1.000	-	-		FOG0000759
OrthoInspector	1	1.000	-	-		otm46272
orthoMCL	1	0.900	-	-		OOG6_101785
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980