Protein Alignment GluClalpha and GABRG3

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_150092.2
• Gene: GABRG3 / 2567
• HGNCID: 4088
• Length: 467
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 147/464 - (31%)
• Similarity: 224/464 - (48%)
• Gaps: 89/464 - (19%)

  Fly    36 VLDQILGAGKYDARIRPS-GINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99
            :|:::|  .:||.::||. ||.    |.|:.|:|:|.||..:..:.|||.:.:.|.:.|||.||:
Human    50 ILNKLL--REYDKKLRPDIGIK----PTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLR 108

  Fly   100 FDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLA 162
            |:   ..:|.|||..  ...:|:||..|.|.|....|.|..||..:||:.:|.:||::|:::...
Human   109 FN---STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170

  Fly   163 CPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVV--KNLHLPRFTLEKFLTDYCNSK 225
            |.:.|..:|:|...|.|..:|||:...::::.|:: :.|:..  |:..|.:|       |:...:
Human   171 CQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRK-NSVEAADQKSWRLYQF-------DFMGLR 227

  Fly   226 -------TNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTT 283
                   |:.|:|..:.:.....|...|:.||.||||.:.|::||||||:.:.|.|||.:||:||
Human   228 NTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITT 292

  Fly   284 LLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKK 348
            :|||.|.::....|||.|||..|:|::..||..|||.||:|:|.:||.|       :..|....|
Human   293 VLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS-------SCRKPTTTK 350

  Fly   349 KRRDL----------EQASLDAASD--LLD---------TDSNATFAMASQFARGGGQQKPLVRH 392
            |...|          |:.||.|.|:  |||         |.:|:.:....:
Human   351 KTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFE-------------- 401

  Fly   393 PGDPLALE--KRLQCEVHMQAPKRPNCCKTWLSKFPTRSKRI-------DVISRITFPLVFALFN 448
              |....|  ....|:...       ||.........|..||       |..||:.||..|.|||
Human   402 --DTCVYECLDGKDCQSFF-------CCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFN 457

  Fly   449 LVYWSTYLF 457
            ||||..||:
Human   458 LVYWVGYLY 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	145/460 (32%)
GABRG3	NP_150092.2	LIC	50..464	CDD:455710	145/460 (32%)
		LGIC_ECD_GABAAR_G	71..252	CDD:349801	54/191 (28%)
		Cys-loop	171..185	CDD:349801	4/13 (31%)