Protein Alignment GluClalpha and GABRA4

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_000800.2
• Gene: GABRA4 / 2557
• HGNCID: 4078
• Length: 554
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 165/553 - (29%)
• Similarity: 251/553 - (45%)
• Gaps: 116/553 - (20%)

  Fly     8 WAILYFASLCSASLANNAKINFREKEK-------KVLDQILGAGKYDARIRPSGINGTDGPAV-V 64
            :|:|.|  ||.|...|.:....:::||       ::||.:|..  ||.|:||    |..||.. |
Human    18 FALLRF--LCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDG--YDNRLRP----GFGGPVTEV 74

  Fly    65 RVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTE--ANRVWMPDLFFSN 127
            :.:|:|.|...:.||.|||::.:.||:.|.|:|||:|   |.::.|.|..  ..:||.||.||.|
Human    75 KTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD---GPIEILRLNNMMVTKVWTPDTFFRN 136

  Fly   128 EKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLV 192
            .|:...||:..||...||..||::||::|::::..|||.|..:|:|...|.|:..||.:..::::
Human   137 GKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMI 201

  Fly   193 FLWKEGDPVQVVKNLHLPRFTLEKFLTDYCNS-------KTNTGEYSCLKVDLLFKREFSYYLIQ 250
            :.|.:|..    |::.:|:.:......|....       |:.||||..:.|....:|:..|::||
Human   202 YTWTKGPE----KSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQ 262

  Fly   251 IYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCL 315
            .||||.|.||:|.||||:::.:||||...|:||:|||.|.:.....|||.|||..|:|.:..||.
Human   263 TYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCF 327

  Fly   316 TFVFGALLEFALVNYASRSGSNKA------------------NMHKE----------NMKKKRRD 352
            .|||.||:|||.|||.:.....||                  ..|.|          ||:|:...
Human   328 AFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNA 392

  Fly   353 LEQASLDAASDL-LDTDSNATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQAPKRPN 416
            |..:..|..:.. :...|:.:..:..:.::|    .|.......|....:....|....|...|:
Human   393 LVHSESDVGNRTEVGNHSSKSSTVVQESSKG----TPRSYLASSPNPFSRANAAETISAARALPS 453

  Fly   417 CCKT----------------------------------------WLSKFPTRS---------KRI 432
            ...|                                        .||..|..|         .:|
Human   454 ASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKI 518

  Fly   433 DVISRITFPLVFALFNLVYWSTYLFRE--EEDE 463
            |..:||.||:.|..||:|||..||.::  |:.|
Human   519 DKYARILFPVTFGAFNMVYWVVYLSKDTMEKSE 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	161/541 (30%)
GABRA4	NP_000800.2	LIC	13..541	CDD:455710	161/541 (30%)
		LGIC_ECD_GABAAR_A4	57..255	CDD:349838	68/210 (32%)
		Cys-loop	172..186	CDD:349838	6/13 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..381		4/30 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..435		5/41 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..471		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..515		4/19 (21%)