DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluClalpha and GABRA3

DIOPT Version :10

Sequence 1:NP_001287408.1 Gene:GluClalpha / 42350 FlyBaseID:FBgn0024963 Length:463 Species:Drosophila melanogaster
Sequence 2:NP_000799.1 Gene:GABRA3 / 2556 HGNCID:4077 Length:492 Species:Homo sapiens


Alignment Length:445 Identity:159/445 - (35%)
Similarity:242/445 - (54%) Gaps:51/445 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 KVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99
            ::||::|..  ||.|:|| |:.  |....|:.:|:|.|...:.|..|||::.:.||:.|.|||||
Human    69 RILDRLLDG--YDNRLRP-GLG--DAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLK 128

  Fly   100 FDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLA 162
            ||   |.:|.|.|..  |:::|.||.||.|.|:...||:..||..:|:..||::||::|:::...
Human   129 FD---GPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAE 190

  Fly   163 CPMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEG--DPVQVVKN-LHLPRFTLEKFLTDYCNS 224
            |||:|:.:|:|...|.|:..||.:||.::|:.|..|  ..|:|.:: ..|.::.|...:......
Human   191 CPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEII 255

  Fly   225 KTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMAT 289
            :::||||..:......||:..|::||.|:||.|.||:|.|||||::.:||||...||||:|||.|
Human   256 RSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTT 320

  Fly   290 QTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNY-ASRSGSNKANMHKE--NMKKKRR 351
            .:.....|||.|:|..|:|.:..||..|||.||:|||.||| ..||.:.:.....|  .||||..
Human   321 LSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTP 385

  Fly   352 DLEQASLDAASDLLDTD------SNATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQ 410
            ...........:::.|.      .:..|:..|:.|.......|.:                  :.
Human   386 AAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTI------------------IA 432

  Fly   411 APKRPNCCKTWLSKFPTRSK------RIDVISRITFPLVFALFNLVYWSTYLFRE 459
            :||     .|::...||.:|      ::|.||||.||::||:||||||:||:.||
Human   433 SPK-----ATYVQDSPTETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRE 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluClalphaNP_001287408.1 LIC 3..455 CDD:273305 155/439 (35%)
GABRA3NP_000799.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..54
LIC 69..478 CDD:455710 155/439 (35%)
LGIC_ECD_GABAAR_A3 75..274 CDD:349837 72/206 (35%)
Cys-loop 191..205 CDD:349837 6/13 (46%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.