DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluClalpha and GABRA2

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001317619.1	Gene:	GABRA2 / 2555	HGNCID:	4076	Length:	511	Species:	Homo sapiens

Alignment Length:	510	Identity:	176/510 - (34%)
Similarity:	258/510 - (50%)	Gaps:	83/510 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 W--AILYFASLCSASLANNAKINFREKEKKVLDQILGAGKYDARIRPSGINGTDGPAVVRVNIFV 70
            |  |.|..|::......||..|..|     :||::|..  ||.|:|| |:.  |....|..||:|
Human    20 WDPARLVLANIQEDEAKNNITIFTR-----ILDRLLDG--YDNRLRP-GLG--DSITEVFTNIYV 74

  Fly    71 RSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHF 133
            .|...:.|..|||::.:.||::|.||||||   :|.:..|.|..  |:::|.||.||.|.|:...
Human    75 TSFGPVSDTDMEYTIDVFFRQKWKDERLKF---KGPMNILRLNNLMASKIWTPDTFFHNGKKSVA 136

  Fly   134 HNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLW--K 196
            ||:.|||..:||..:|::||::|:::...|||:|:.:|:|...|.|:..||.:||:::.::|  .
Human   137 HNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYN 201

  Fly   197 EGDPVQVVKN-LHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVI 260
            ..|.|||..: ..|.::.|..........|::||||:.:......||:..|::||.|:||.|.||
Human   202 ASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVI 266

  Fly   261 VSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEF 325
            :|.|||||::.:||||...||||:|||.|.:.....|||.|:|..|:|.:..||..|||.||:||
Human   267 LSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEF 331

  Fly   326 ALVNYASR-----SGSNKANMHKENMKKKRRDLEQASLDA--ASDLLDTDSNATFAMASQFARGG 383
            |.|||.::     .|.:..|....::|.:...|...|:.|  ....|.......|:..|.|
Human   332 ATVNYFTKRGWAWDGKSVVNDKSPSIKAEGITLTYNSVKAILQGAKLIWSKYIAFSWPSLF---- 392

  Fly   384 GQQKPLVRHPGDPLALEKRLQCEVHMQAPKR--------------------PNCCK----TWLSK 424
             |:|.|.       .|||.:.|....|:.|:                    ||..|    :.:||
Human   393 -QEKTLE-------YLEKWMDCLTFKQSSKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISK 449

  Fly   425 F-------------PTRSK-------RIDVISRITFPLVFALFNLVYWSTYLFRE 459
            .             |..:|       :||.:|||.||::|..||||||:|||.||
Human   450 SATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNRE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	171/504 (34%)
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	169/499 (34%)
GABRA2	NP_001317619.1	LGIC_ECD_GABAAR_A2	47..249	CDD:349836	74/209 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910