DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and Glra2

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001344028.1	Gene:	Glra2 / 237213	MGIID:	95748	Length:	452	Species:	Mus musculus

Alignment Length:	436	Identity:	191/436 - (43%)
Similarity:	258/436 - (59%)	Gaps:	45/436 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LDQILG-AGKYDARIRPSGINGTDGPAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99
            ||:::| ...|||||||:    ..||.| |..|||:.|...:.:.||:|.|.:..|:||.|.||.
Mouse    48 LDKLMGRTSGYDARIRPN----FKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLA 108

  Fly   100 FDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACP 164
            :.:.......|..:..:.:|.|||||:|||..:||::...|..:||..||.||||||::|||:||
Mouse   109 YSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCP 173

  Fly   165 MNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTN 227
            |:||.:|:|.|.|::::.|:|:|.|||:|.|....||||.:.|.||:|.|  ||.| .||....|
Mouse   174 MDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKEL-GYCTKHYN 237

  Fly   228 TGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTS 292
            ||:::|::|....:|:..|||||:|||..::||:||||||::..|.||||:||:||:|||.||:|
Mouse   238 TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSS 302

  Fly   293 GINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKKRRDLEQAS 357
            |..||||.|||.||||:|..|||.|||.||||:|.||:.||       .|||.::.:||...|..
Mouse   303 GSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSR-------QHKEFLRLRRRQKRQNK 360

  Fly   358 LDAASDLLDTDSNATFAMASQFARGGG---QQK---PLVRHPGDPLALEKRLQCEVHMQAPKRPN 416
            .:      |....:.|..:..   |.|   |.|   .:...|.:||.           |.||..:
Mouse   361 EE------DVTRESRFNFSGY---GMGHCLQMKDGTAVKATPANPLP-----------QPPKDAD 405

  Fly   417 CCKTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTYLFREEED 462
            ..|   .||..|:||||.|||..|||.|.:||:.||.||.....||
Mouse   406 AIK---KKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHED 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	187/427 (44%)
Glra2	NP_001344028.1	LIC	46..441	CDD:273305	187/427 (44%)
Glra2	NP_001344028.1	Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	236..241		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3629
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2310
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	1	1.000	-	-		FOG0000759
OrthoInspector	1	1.000	-	-		otm44180
orthoMCL	1	0.900	-	-		OOG6_101785
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980