DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluClalpha and Gabrr3

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_620252.1	Gene:	Gabrr3 / 192258	RGDID:	621564	Length:	464	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	144/441 - (32%)
Similarity:	233/441 - (52%)	Gaps:	57/441 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DQILGAGKYDARIRPSGINGTDGPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDD 102
            :|:|....:|...|| |..|:  |..|.:::.|.||..|.:|.|::::....|..|.||||.|..
  Rat    59 EQLLHIEDHDFSTRP-GFGGS--PVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPS 120

  Fly   103 IQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNL 167
            ...:..........::|:||:||.:.|....|:..:.|:.:|:.|:|:||:|:||:::..|.|:.
  Rat   121 TTNKSMTFDRRLIQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDF 185

  Fly   168 KLYPLDRQICSLRMASYGWTTNDLVFLWKEGD-PVQVVKNLHLPRFTLEKF-----LTDYCNSKT 226
            ..:|||.|.|||.:.||.:...||:..||.|: .:...:::.|.:|.:|:|     |..|    :
  Rat   186 SRFPLDTQNCSLELESYAYNEEDLMLYWKHGNKSLNTEEHISLSQFFIEEFSASSGLAFY----S 246

  Fly   227 NTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQT 291
            :||.|..|.::.:.:|...::::|.|.|..::|::||||||:|:.|||||||||:||:|||:|..
  Rat   247 STGWYYRLFINFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIV 311

  Fly   292 SGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKKRR----- 351
            :|::||:|.|||.||:||:..|...|||.:::|:|.|||.:.         .|..|:..|
  Rat   312 TGVSASMPQVSYVKAVDVYMWVSSLFVFLSVIEYAAVNYLTT---------VEEWKQLNRRGKIS 367

  Fly   352 -----DLEQA-SLDAASDLLDTDSNAT-FAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHM 409
                 |..|| :.|......:||.:.| |.:.|:      :.....:..|.|.|...::
  Rat   368 GMYNIDAVQAMAFDGCYHDGETDVDQTSFFLHSE------EDSMRTKFTGSPCADSSQI------ 420

  Fly   410 QAPKRP----NCCKTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTYL 456
               ||.    |..:..|.    .:..||..|||.||:|:.:|||.||..|:
  Rat   421 ---KRKSLGGNVGRIILE----NNHVIDTYSRIVFPVVYIIFNLFYWGIYV 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	143/438 (33%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:273305	143/438 (33%)
		LGIC_ECD	79..264	CDD:355788	58/188 (31%)
		Cys-loop	181..195	CDD:349787	6/13 (46%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:12431995	344..445		26/128 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910