DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluClalpha and glra4b

DIOPT Version :9

Sequence 1:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001189440.1	Gene:	glra4b / 192125	ZFINID:	ZDB-GENE-020402-2	Length:	492	Species:	Danio rerio

Alignment Length:	446	Identity:	185/446 - (41%)
Similarity:	264/446 - (59%)	Gaps:	27/446 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LDQILG-AGKYDARIRPSGINGTDGPAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99
            ||:::| ...|||||||:    ..||.| |..|||:.|...|.:.||:|.:.:..|:||.|.||.
Zfish    47 LDKLMGKTSGYDARIRPN----FKGPPVNVTCNIFINSFGSITETTMDYRLNVFLRQQWNDPRLA 107

  Fly   100 FDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACP 164
            :.:.......|..:..:.:|.|||||:|||..:||.:...|..:|||.||:||||||::|.|:||
Zfish   108 YKEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFQNGNVLYSIRLTLILSCP 172

  Fly   165 MNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTN 227
            |:||.:|:|.|.|::::.|:|:|.|||:|.|.:..||||..:|.||:|.|  ||.| .||....|
Zfish   173 MDLKNFPMDTQTCTMQLESFGYTMNDLIFQWLDEGPVQVADDLMLPQFVLKEEKDL-GYCTKHYN 236

  Fly   228 TGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTS 292
            ||:::|::|....:|:..|||||:|||..:.||:||||||::..|.||||.||:||:|||.||:|
Zfish   237 TGKFTCIEVKFHLERQMGYYLIQMYIPSLLTVILSWVSFWINMDAAPARVGLGITTVLTMTTQSS 301

  Fly   293 GINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKKRRDLEQAS 357
            |..||||.|||.||||:|..|||.|||.||||:|.||:.||.......:.:: :::::|:...:.
Zfish   302 GSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQYKEFFRLRRK-LRQEQRNRAASG 365

  Fly   358 LDAASDLLDTDSNATFAMASQFARG-----------GGQQKPLVRHPG----DPLALEKRLQCEV 407
            ...|::..:..:|.|....|:.|:.           ..|.:.|. .||    ..|:.:..|....
Zfish   366 QAGAAETKNKSNNVTGGTPSRNAQRQCSACAREEQLASQNQDLY-FPGFGIDTSLSGDGPLSEAA 429

  Fly   408 HMQAPKRP-NCCKTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTYLFREEED 462
            .|.|...| :.......:|..::||||.|||..|||.|.:||:.||.||.....||
Zfish   430 AMFAGLPPGHALFDIRRRFVEQAKRIDTISRAVFPLSFLVFNVFYWVTYKVLRNED 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	181/437 (41%)
glra4b	NP_001189440.1	LIC	5..478	CDD:273305	181/437 (41%)
		Neur_chan_LBD	47..253	CDD:280998	91/210 (43%)
		Neur_chan_memb	260..475	CDD:280999	83/216 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3541
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	345	1.000	Inparanoid score	I2297
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	1	1.000	-	-		FOG0000759
OrthoInspector	1	1.000	-	-		otm24998
orthoMCL	1	0.900	-	-		OOG6_101785
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970