Protein Alignment GluClalpha and lgc-52

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_502839.3
• Gene: lgc-52 / 190669
• WormBaseID: WBGene00013517
• Length: 423
• Species: Caenorhabditis elegans
• Alignment Length: 424
• Identity: 119/424 - (28%)
• Similarity: 191/424 - (45%)
• Gaps: 70/424 - (16%)

  Fly    53 SGINGTD-----------------GPAVVRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLKF 100
            ||...||                 .|..|.|.|.::.||.|..:|..:::.......|.|:||.|
 Worm    41 SGAKATDLARILMTNYSRNALPEPAPVKVEVEITIQDISDISAITGTFTIDYWISAIWNDKRLAF 105

  Fly   101 DDIQGRLKYLTLTE--ANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLAC 163
            ..:....|.|:|..  ..::|.|::...|.|....|:...||:.:.|||||::..:.||.....|
 Worm   106 SHLDPCRKNLSLDHDMEPKLWSPNVCIVNSKSTKVHDSPKPNILLMIFPNGTIWLNYRIRSEAPC 170

  Fly   164 PMNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKN-LHLPRFTLEKFLTDYCNSKTN 227
            .|||:.:|||...|||...||.:...|:...|.|..||..|:| .:||.|.:.............
 Worm   171 QMNLRNFPLDSIRCSLVFESYSYNAADVELQWLEWSPVSTVRNDYNLPDFRMTNITYGSVTEAYT 235

  Fly   228 TGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTS 292
            .|.:..|.|.:.|:|.:.:|::|:|:|..:.|.:||::||:|..|:|||::|.|::|:.:..|..
 Worm   236 AGMWHRLSVSIHFERLYGFYILQMYLPTYISVFISWIAFWMDTKALPARITLSVSSLMALTFQFG 300

  Fly   293 GINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKKRRDLEQAS 357
            .|..|||..||.||||:|...|:.|:|.:|:|.|:|.|..:       ||.:.:::.|..:...:
 Worm   301 NIVKSLPKASYVKAIDIWMFSCVGFIFFSLIELAIVAYNDK-------MHDQRLREVRCSVGNLN 358

  Fly   358 LDAASDLLDTDSNATFAMASQFARGGGQQKPLVRHPGDPLALEKRLQCEVHMQAPKRPNCCKTWL 422
            .:.......|...:...::::.|:|.
 Worm   359 SNGIGQYNSTTRRSFVELSARRAKGS--------------------------------------- 384

  Fly   423 SKFPTRSKRIDVISRITFPLVFALFNLVYWSTYL 456
                .....||.::.:.||.:|||||||||:.||
 Worm   385 ----ELGASIDRVASMLFPTMFALFNLVYWAYYL 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	117/421 (28%)
lgc-52	NP_502839.3	LGIC_ECD_GABAAR	67..250	CDD:349791	55/182 (30%)
		Cys-loop	170..184	CDD:349791	7/13 (54%)
		LGIC_TM_anion	254..410	CDD:349851	54/205 (26%)
		TM1 helix	254..277	CDD:349851	9/22 (41%)
		TM2 helix	281..305	CDD:349851	8/23 (35%)
		TM3 helix	313..376	CDD:349851	17/69 (25%)
		TM4 helix	377..410	CDD:349851	13/75 (17%)