Protein Alignment GluClalpha and lgc-51

DIOPT Version :10

• Sequence 1: NP_001287408.1
• Gene: GluClalpha / 42350
• FlyBaseID: FBgn0024963
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_001293359.1
• Gene: lgc-51 / 184377
• WormBaseID: WBGene00017399
• Length: 450
• Species: Caenorhabditis elegans
• Alignment Length: 471
• Identity: 139/471 - (29%)
• Similarity: 220/471 - (46%)
• Gaps: 56/471 - (11%)

  Fly    10 ILYFASLCSASLANNAKINFREKEKK-------VLDQILGAGKYDARIRPSGINGTDGPAVVRVN 67
            :.:|.::...:.|.: :.:|.||..|       :||.|:  ..| :|..|.      .|..|:|.
 Worm     3 LFHFLAVIVTTFAQD-EGSFVEKCTKPRLTPAAILDVIM--ANY-SRSLPG------NPVGVQVE 57

  Fly    68 IFVRSISKIDDVTMEYSVQLTFREQWTDERLKFDDIQGRLKYLTLTE--ANRVWMPDLFFSNEKE 130
            :.|:.:.::..::..::..:.|...|.|.||.:..:....:.|:..:  ...:|.|::...|.|.
 Worm    58 VTVQDVMELSVLSNSFTADIWFSSIWYDPRLAYSHLDNCRQNLSFDDRFEKLIWSPNVCIVNTKS 122

  Fly   131 GHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACPMNLKLYPLDRQICSLRMASYGWTTNDLVFLW 195
            .|.|....|||.:.:.|||::..:.||.:...|.|:|..:|:|.|.|.|...||.:.|..:...|
 Worm   123 AHVHRSPKPNVLLMLLPNGTIWLNYRIRVQSPCSMDLARFPIDTQYCQLVFESYSYNTASVSVNW 187

  Fly   196 KEGDPVQVVKNLHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVI 260
            . .:||.|:..:.|..|.|.::.|.........||:..|.|:..|.|::.:|::|:|:|..:.:.
 Worm   188 M-ANPVTVLPEISLADFDLSRYRTSRHTEVYKAGEWYRLTVEFEFTRKYGFYILQLYVPTYISLF 251

  Fly   261 VSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEF 325
            :||::|.:|..|:|||:.|||.:|:::..|...|..|||||||.||||:|...|:.|:|.:|||.
 Worm   252 ISWIAFCIDTKALPARIVLGVNSLMSLTFQFGNIIRSLPPVSYVKAIDLWMCTCVGFIFASLLEL 316

  Fly   326 ALVNYAS-----RSGSNKANM--------HKENMKKKRRDLEQASLDAASDLLDTDSNATFAMAS 377
            |.|.|..     :||.:.|.:        |.|...........|.||....:..|.|..|....|
 Worm   317 AFVAYQDKKLILKSGKSNAAISTLVSYLKHFEPYHDVSSPPPPAPLDEKKSMSRTTSTGTNRSRS 381

  Fly   378 QFARGGGQQKPLVRHPG-DPLALEKRLQCEVHMQAPKRPNCCKTW-LSKFPTRSKRIDVISRITF 440
            :.             .| |...||:.: .|....|..|    |.| |..|   ...:|.||.|.|
 Worm   382 EL-------------DGLDTKDLEEEI-AEYRKLAYAR----KKWRLLDF---GANVDRISFIVF 425

  Fly   441 PLVFALFNLVYWSTYL 456
            ||.||.||:|||:.||
 Worm   426 PLTFAAFNVVYWTYYL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	137/468 (29%)
lgc-51	NP_001293359.1	LIC	34..440	CDD:455710	131/436 (30%)
		LGIC_ECD_GABAAR	52..233	CDD:349791	47/181 (26%)
		Cys-loop	155..169	CDD:349791	6/13 (46%)